Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Two opposing models have been proposed to describe the function of the MYC oncoprotein
in shaping cellular transcriptomes: one posits that MYC amplifies transcription at all active …

The ability of circulating tumor cells (CTCs) to form clusters has been linked to increased
metastatic potential. Yet biological features and vulnerabilities of CTC clusters remain …

Summary Oct4, Sox2, Klf4, and cMyc (OSKM) reprogram somatic cells to pluripotency. To
gain a mechanistic understanding of their function, we mapped OSKM-binding, stage …

Summary Master transcription factors Oct4, Sox2, and Nanog bind enhancer elements and
recruit Mediator to activate much of the gene expression program of pluripotent embryonic …

Embryonic stem cell (ESC) culture conditions are important for maintaining long-term self-
renewal, and they influence cellular pluripotency state. Here, we report single cell RNA …

DNase I hypersensitive sites (DHSs) are markers of regulatory DNA and have underpinned
the discovery of all classes of cis-regulatory elements including enhancers, promoters …

Pioneer transcription factors have the ability to access DNA in compacted chromatin.
Multiple transcription factors can bind together to a regulatory element in a cooperative way …

Transcription factors (TFs) bind specific sequences in promoter-proximal and-distal DNA
elements to regulate gene transcription. RNA is transcribed from both of these DNA …

Stem cells self-renew and generate specialized progeny through differentiation, but vary in
the range of cells and tissues they generate, a property called developmental potency …