Intrinsic and extrinsic pathways of apoptosis: Role in cancer development and prognosis
Apoptosis, also named programmed cell death, is a fundament process required for
morphogenetic homeostasis during early development and in pathophysiological …
morphogenetic homeostasis during early development and in pathophysiological …
Caspases and their substrates
Protease biology is intimately linked to the functional consequences of substrate cleavage
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …
events. Human caspases are a family of 12 fate-determining cysteine proteases that are best …
Caspase-1 engages full-length gasdermin D through two distinct interfaces that mediate caspase recruitment and substrate cleavage
The recognition and cleavage of gasdermin D (GSDMD) by inflammatory caspases-1, 4, 5,
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …
and 11 are essential steps in initiating pyroptosis after inflammasome activation. Previous …
Mechanism of gasdermin D recognition by inflammatory caspases and their inhibition by a gasdermin D-derived peptide inhibitor
The inflammasomes are signaling platforms that promote the activation of inflammatory
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
caspases such as caspases-1,-4,-5, and-11. Recent studies identified gasdermin D …
Caspase substrates and inhibitors
M Poręba, A Stróżyk… - Cold Spring Harbor …, 2013 - cshperspectives.cshlp.org
Caspases are proteases at the heart of networks that govern apoptosis and inflammation.
The past decade has seen huge leaps in understanding the biology and chemistry of the …
The past decade has seen huge leaps in understanding the biology and chemistry of the …
Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD
Caspase-1 drives a lytic inflammatory cell death named pyroptosis by cleaving the pore-
forming cell death executor gasdermin-D (GSDMD). Gsdmd deficiency, however, only …
forming cell death executor gasdermin-D (GSDMD). Gsdmd deficiency, however, only …
Guanidine–curcumin complex-loaded amine-functionalised hollow mesoporous silica nanoparticles for breast cancer therapy
Simple Summary The combination of guanidine carbonate and curcumin-loaded hollow
mesoporous silica nanoparticles (GuC-HMSNAP) can be used as a therapeutic and to …
mesoporous silica nanoparticles (GuC-HMSNAP) can be used as a therapeutic and to …
Quantitative MS-based enzymology of caspases reveals distinct protein substrate specificities, hierarchies, and cellular roles
Proteases constitute the largest enzyme family, yet their biological roles are obscured by our
rudimentary understanding of their cellular substrates. There are 12 human caspases that …
rudimentary understanding of their cellular substrates. There are 12 human caspases that …
Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1
Inflammatory cell death, or pyroptosis, is triggered by pathogenic infections or events. It is
executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical …
executed by caspase-1 (in the canonical pyroptosis pathway) or caspase-11 (noncanonical …
Multiple mechanisms of zinc-mediated inhibition for the apoptotic caspases-3,-6,-7, and-8
SJ Eron, DJ MacPherson, KB Dagbay… - ACS chemical …, 2018 - ACS Publications
Zinc is emerging as a widely used and important biological regulatory signal. Cellular zinc
levels are tightly regulated by a complex array of zinc importers and exporters to control …
levels are tightly regulated by a complex array of zinc importers and exporters to control …