Liver X receptors α and β (LXRα and LXRβ) are nuclear receptors with pivotal roles in the
transcriptional control of lipid metabolism. Transcriptional activity of LXRs is induced in …

Teleost fish possess an adaptive immune system associated with each of their mucosal
body surfaces. Evidence obtained from mucosal vaccination and mucosal infection studies …

Blood high-density lipoprotein (HDL) levels are inversely related to risk for cardiovascular
disease, implying that factors associated with HDL metabolism are atheroprotective. One of …

RAB, ADP-ribosylation factors (ARFs) and ARF-like (ARL) proteins belong to the Ras
superfamily of small GTP-binding proteins and are essential for various membrane …

Plasma levels of high-density lipoproteins (HDL) and apolipoprotein AI (apoA-I) are
inversely correlated with the risk of cardiovascular disease. One major atheroprotective …

The ATP-binding cassette transporters, ABCA1 and ABCG1, are major players in mediating
cellular efflux of phospholipids and cholesterol to apoA-I containing lipoproteins including …

Cellular cholesterol levels are tightly regulated and represent a balance of cholesterol
uptake, endogenous synthesis and efflux. Although the classic transcriptional regulations of …

We recently demonstrated that expression of ADP-ribosylation factor (ARF)-like 4c (Arl4c)
induced by a combination of Wnt/β-catenin and epidermal growth factor/Ras signaling in …

Summary The small GTPase Arf6 regulates endocytosis, actin dynamics, and cell adhesion,
and one of its major activators is the exchange factor Arf nucleotide-binding site opener …

Diabetic retinopathy (DR) is a leading cause of preventable blindness in adults. To identify
genetic contributions in DR, we studied 2071 type 2 diabetics. We first conducted a genome …