The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …

To define the cellular composition and architecture of cutaneous squamous cell carcinoma
(cSCC), we combined single-cell RNA sequencing with spatial transcriptomics and …

Spatial and molecular characteristics determine tissue function, yet high-resolution methods
to capture both concurrently are lacking. Here, we developed high-definition spatial …

Progressive multiple sclerosis (MS) is characterized by unrelenting neurodegeneration,
which causes cumulative disability and is refractory to current treatments. Drug development …

Reconstruction of heterogeneity through single cell transcriptional profiling has greatly
advanced our understanding of the spatial liver transcriptome in recent years. However …

The spatial organization of cells and molecules plays a key role in tissue function in
homeostasis and disease. Spatial transcriptomics has recently emerged as a key technique …

Rapid cost drops and advancements in next-generation sequencing have made profiling of
cells at individual level a conventional practice in scientific laboratories worldwide. Single …

Spatial resolution of gene expression enables gene expression events to be pinpointed to a
specific location in biological tissue. Spatially resolved gene expression in tissue sections is …

Background Multiple sclerosis (MS), an autoimmune disease of the central nervous system
(CNS), can be suppressed in its early stages but eventually becomes clinically progressive …