Neuroprotection by agmatine: Possible involvement of the gut microbiome?
P Saha, S Panda, A Holkar, R Vashishth… - Ageing Research …, 2023 - Elsevier
Agmatine, an endogenous polyamine derived from L-arginine, elicits tremendous
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …
multimodal neuromodulant properties. Alterations in agmatinergic signalling are closely …
Agmatine: multifunctional arginine metabolite and magic bullet in clinical neuroscience?
G Laube, HG Bernstein - Biochemical Journal, 2017 - portlandpress.com
Agmatine, the decarboxylation product of arginine, was largely neglected as an important
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …
player in mammalian metabolism until the mid-1990s, when it was re-discovered as an …
[HTML][HTML] Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus
(T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain …
(T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain …
Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke
Stroke is a severe neurological disorder characterized by the abrupt loss of blood circulation
into the brain resulting into wide ranging brain and behavior abnormalities. The present …
into the brain resulting into wide ranging brain and behavior abnormalities. The present …
Neuroprotective offerings by agmatine
NR Kotagale, BG Taksande, NN Inamdar - Neurotoxicology, 2019 - Elsevier
Agmatine, an endogenous polyamine in CNS, is derived from arginine by dearboxylation.
Like polyamines, agmatine has been studied for its neuroprotetive effects. At present, a large …
Like polyamines, agmatine has been studied for its neuroprotetive effects. At present, a large …
Agmatine modulates anxiety and depression-like behaviour in diabetic insulin-resistant rats
Epidemiological studies indicated that mood disorders like depression and anxiety are
highly prevalent in type-II diabetes mellitus (T2DM). However, the neurobiological …
highly prevalent in type-II diabetes mellitus (T2DM). However, the neurobiological …
Agmatine, a potential novel therapeutic strategy for depression
Major depressive disorder is the most common psychiatric disorder with lifetime prevalence
of up to 20% worldwide. It is responsible for more years lost to disability than any other …
of up to 20% worldwide. It is responsible for more years lost to disability than any other …
Administration of agmatine prior to physical or psychological stress in pregnant mice ameliorates behavioural and cognitive deficits in female offspring
A Hassanshahi, M Janahmadi… - International Journal …, 2023 - Wiley Online Library
Physical or psychological stress experienced by a mother during gestation is often
associated with serious behavioural and cognitive deficits in newborns. Investigations of …
associated with serious behavioural and cognitive deficits in newborns. Investigations of …
Exploring the clinical connections between epilepsy and diabetes mellitus: Promising therapeutic strategies utilizing agmatine and metformin
Purpose Diabetes mellitus (DM) and epilepsy and the psychological and socio-economic
implications that are associated with their treatments can be quite perplexing. Metformin is …
implications that are associated with their treatments can be quite perplexing. Metformin is …
Protective effects of agmatine on lipopolysaccharide-injured microglia and inducible nitric oxide synthase activity
AIMS: Proinflammatory factors released from activated microglia contribute to maintaining
homeostasis against various noxious stimuli in the central nervous system. If excessive …
homeostasis against various noxious stimuli in the central nervous system. If excessive …