[HTML][HTML] A comprehensive review of integrative pharmacology-based investigation: A paradigm shift in traditional Chinese medicine

H Xu, Y Zhang, P Wang, J Zhang, H Chen… - … Pharmaceutica Sinica B, 2021 - Elsevier
Over the past decade, traditional Chinese medicine (TCM) has widely embraced systems
biology and its various data integration approaches to promote its modernization. Thus …

Clinical evaluation of postoperative analgesia, cardiorespiratory parameters and changes in liver and renal function tests of paracetamol compared to meloxicam and …

I Hernández-Avalos, A Valverde… - PLoS …, 2020 - journals.plos.org
Background In veterinary medicine, the administration of nonsteroidal anti-inflammatory
analgesics (NSAIDs) for the control of postsurgical pain in dogs and cats is common given …

Intravenous acetaminophen does not provide adequate postoperative analgesia in dogs following ovariohysterectomy

J Leung, T Beths, JE Carter, R Munn, T Whittem… - Animals, 2021 - mdpi.com
Simple Summary Acetaminophen is the most commonly used pain relief (analgesic) agent in
humans worldwide and its use is becoming more frequent in dogs. However, limited …

Comparison of the effects on lameness of orally administered acetaminophen-codeine and carprofen in dogs with experimentally induced synovitis

SC Budsberg, SA Kleine, MM Norton… - American Journal of …, 2020 - Am Vet Med Assoc
OBJECTIVE To compare the ability of acetaminophen-codeine (AC; 15.5 to 18.5 mg/kg and
1.6 to 2.0 mg/kg, respectively) or carprofen (4.2 to 4.5 mg/kg) administered PO to attenuate …

Pharmacokinetics of acetaminophen after intravenous and oral administration in fasted and fed Labrador Retriever dogs

I Sartini, B Łebkowska‐Wieruszewska… - Journal of Veterinary …, 2021 - Wiley Online Library
Acetaminophen (paracetamol) is used in dogs to manage fever and mild pain. The aim of
this study was to assess the pharmacokinetics of acetaminophen in both fed and fasted …

Pharmacokinetic profile of oral and subcutaneous administration of paracetamol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy

M Govendir, L Vogelnest, AJ Shapiro, C Marschner… - Plos one, 2024 - journals.plos.org
The pharmacokinetic profile of paracetamol in koalas is described when administered orally
at 15 mg/kg; followed by the same dose, administered every 12 hours (hrs), repeated five …

Paracetamol: A focus on dogs

C Fadel, I Sartini, M Giorgi - American Journal of Animal and …, 2021 - arpi.unipi.it
Paracetamol (APAP) is an aniline analgesic, antipyretic and non-narcotic. It is an essential
drug, widely used in human medicine. In veterinary medicine it has an extra label use in …

Complementary HPLC, in silico toxicity, and molecular docking studies for investigation of the potential influences of gastric acidity and nitrite content on paracetamol …

R El-Shaheny, T Fuchigami, S Yoshida… - Microchemical …, 2019 - Elsevier
This study was initiated for investigating the possible gastro-transformations that may affect
the integrity and safety of the most commonly administered analgesic and antipyretic …

Acetaminophen and tramadol hydrochloride-loaded soft gelatin capsule: preparation, dissolution and pharmacokinetics in beagle dogs

JH Cho, HG Choi - Pharmaceutical Development and Technology, 2021 - Taylor & Francis
The objective of this study was to develop a novel acetaminophen and tramadol
hydrochloride-loaded soft capsule (ATSC) with enhanced bioavailability of tramadol. The …

Effects of a single paracetamol injection on the sevoflurane minimum alveolar concentration in dogs

P González-Blanco, S Canfrán, R Mota… - Canadian Journal of …, 2020 - ingentaconnect.com
This study aimed to determine the effect of a single injection of paracetamol on the
sevoflurane minimum alveolar concentration (MAC) response to noxious mechanical …