Site-specific phosphorylation is a fast and reversible covalent post-translational modification
that is tightly regulated in cells. The cellular machinery of enzymes that write, erase and read …

Traumatic life experiences are associated with alcohol use problems, an association that is
likely to be moderated by genetic predisposition. To understand these interactions, we …

Neurotransmitter release is mediated by the fast, calcium-triggered fusion of synaptic
vesicles with the presynaptic plasma membrane, followed by endocytosis and recycling of …

Protein acetylation, one of many types of post-translational modifications (PTMs), is involved
in a variety of biological and cellular processes. In the present study, we applied both CsCl …

Mice lacking wild-type p53-induced phosphatase 1 (Wip1) display male reproductive defects
including smaller testes, subfertility and spermatogenesis defects at the round-and …

Nm23/NME was identified 30 years ago as the first metastatic gene suppressor family.
Despite extensive studies, the mechanism of action behind the observed antimetastatic …

Cerebellum is devoted to motor coordination and cognitive functions. Endoplasmic reticulum
is the largest intracellular calcium store involved in all neuronal functions. Intralumenal …

Quantitative proteomics and phosphoproteomics have become key disciplines in
understanding cellular processes. Fundamental research can be done using cell culture …

In the cell the second messenger cyclic nucleotides cAMP and cGMP mediate a wide variety
of external signals. Both signaling molecules are degraded by the superfamily of …

The cerebellum improves motor performance by adjusting motor gain appropriately. As de
novo protein synthesis is essential for the formation and retention of memories, we …