Role of oxidative modifications in atherosclerosis

R Stocker, JF Keaney Jr - Physiological reviews, 2004 - journals.physiology.org
This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Role of oxidized low density lipoprotein in atherogenesis.

JL Witztum, D Steinberg - The Journal of clinical …, 1991 - Am Soc Clin Investig
Evidence to support an important role of oxidative modification in mediating the
atherogenicity of LDL continues to grow. New hypotheses suggest mechanisms by which Ox …

The role of lipid peroxidation and antioxidants in oxidative modification of LDL

H Esterbauer, J Gebicki, H Puhl, G Jürgens - Free Radical Biology and …, 1992 - Elsevier
The purpose of this study is to provide a comprehensive survey on the compositional
properties of LDL (eg, lipid classes, fatty acids, antioxidants) relevant for its susceptibility to …

An integrated hypothesis that considers drusen as biomarkers of immune-mediated processes at the RPE-Bruch's membrane interface in aging and age-related …

GS Hageman, PJ Luthert, NHV Chong… - Progress in retinal and …, 2001 - Elsevier
Age-related macular degeneration (AMD) is a blinding disease that afflicts millions of adults
in the Western world. Although it has been proposed that a threshold event occurs during …

Cytokine expression in advanced human atherosclerotic plaques: dominance of pro-inflammatory (Th1) and macrophage-stimulating cytokines

J Frostegård, AK Ulfgren, P Nyberg, U Hedin… - Atherosclerosis, 1999 - Elsevier
The atherosclerotic lesion contains large numbers of macrophages and T lymphocytes. This
suggests that a cellular immune response may take place in the lesion, and oxidized …

The role of oxidative stress in the onset and progression of diabetes and its complications: asummary of a Congress Series sponsored byUNESCO‐MCBN, the …

P Rösen, PP Nawroth, G King, W Möller… - Diabetes/metabolism …, 2001 - Wiley Online Library
This review summarises the results and discussions of an UNESCO‐MCBN supported
symposium on oxidative stress and its role in the onset and progression of diabetes. There is …

Retroperitoneal fibrosis

A Vaglio, C Salvarani, C Buzio - The Lancet, 2006 - thelancet.com
Retroperitoneal fibrosis encompasses a range of diseases characterised by the presence of
a fibro-inflammatory tissue, which usually surrounds the abdominal aorta and the iliac …

Immune mechanisms in atherosclerosis

GK Hansson - Arteriosclerosis, thrombosis, and vascular biology, 2001 - Am Heart Assoc
Atherosclerosis is an inflammatory disease. Its lesions are filled with immune cells that can
orchestrate and effect inflammatory responses. In fact, the first lesions of atherosclerosis …

Autoantibody against oxidised LDL and progression of carotid atherosclerosis

JT Salonen, H Korpela, R Salonen, K Nyyssonen… - The Lancet, 1992 - Elsevier
Oxidative modification of LDL renders it immunogenic and autoantibodies to epitopes of
oxidised LDL, such as malondialdehyde (MDA)-lysine, are found in serum and recognise …

Low density lipoprotein undergoes oxidative modification in vivo.

W Palinski, ME Rosenfeld… - Proceedings of the …, 1989 - National Acad Sciences
It has been proposed that low density lipoprotein (LDL) must undergo oxidative modification
before it can give rise to foam cells, the key component of the fatty streak lesion of …