The interaction between ferroptosis and inflammatory signaling pathways

Y Chen, ZM Fang, X Yi, X Wei, DS Jiang - Cell death & disease, 2023 - nature.com
Ferroptosis is an iron-dependent regulated cell death driven by excessive lipid peroxidation.
Inflammation is one common and effective physiological event that protects against various …

Molecular and therapeutic insights of alpha-lipoic acid as a potential molecule for disease prevention

AK Tripathi, AK Ray, SK Mishra, SM Bishen… - Revista Brasileira de …, 2023 - Springer
Alpha-lipoic acid is an organic, sulfate-based compound produced by plants, humans, and
animals. As a potent antioxidant and a natural dithiol compound, it performs a crucial role in …

[HTML][HTML] The antagonistic effect of selenium on lead-induced apoptosis and necroptosis via P38/JNK/ERK pathway in chicken kidney

Z Miao, Z Miao, X Shi, H Wu, Y Yao, S Xu - … and environmental safety, 2022 - Elsevier
Lead (Pb), as a toxic heavy metal pollutant, has been paid much attention. Pb is often
discharged into the environment through the soot, wastewater and waste residue in …

Renal-protective roles of lipoic acid in kidney disease

SF Kamt, J Liu, LJ Yan - Nutrients, 2023 - mdpi.com
The kidney is a crucial organ that eliminates metabolic waste and reabsorbs nutritious
elements. It also participates in the regulation of blood pressure, maintenance of electrolyte …

Alpha-lipoic acid: An antioxidant with anti-aging properties for disease therapy

M Shanaida, R Lysiuk, O Mykhailenko… - Current Medicinal …, 2025 - benthamdirect.com
The anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human
tissues, have attracted a growing interest in recent years. αLA is a short-chain sulfur …

[HTML][HTML] Ferroptosis in Cancer: Epigenetic Control and Therapeutic Opportunities

R Veglia Tranchese, S Battista, L Cerchia, M Fedele - Biomolecules, 2024 - mdpi.com
Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, has
emerged as a critical pathway in cancer biology. This review delves into the epigenetic …

SIRT3 deficiency sensitizes angiotensin-II-induced renal fibrosis

X Feng, H Su, X He, JX Chen, H Zeng - Cells, 2020 - mdpi.com
Background: Sirtuin 3 (SIRT3) has a crucial role in the cardiovascular diseases. Our
previous study revealed that SIRT3 knockout (SIRT3KO) promoted cardiac pericyte …

Chia seeds and coenzyme Q10 alleviate iron overload induced hepatorenal toxicity in mice via iron chelation and oxidative stress modulation

SA Sadek, M Marzouk, HRH Mohamed… - Scientific Reports, 2023 - nature.com
Iron overload (IOL) can cause hepatorenal damage due to iron-mediated oxidative and
mitochondrial damage. Remarkably, combining a natural iron chelator with an antioxidant …

Alpha-lipoic acid as a nutritive supplement for humans and animals: an overview of its use in dog food

RM Anthony, JM MacLeay, KL Gross - Animals, 2021 - mdpi.com
Simple Summary A review of human and animal studies involving alpha-lipoic acid
supplementation was conducted to determine the utility of alpha-lipoic acid in dog food. The …

Pharmacological agents for the prevention of colistin-induced nephrotoxicity

M Mirjalili, E Mirzaei, A Vazin - European Journal of Medical Research, 2022 - Springer
Background Colistin is a polymyxin antibiotic which has been used for treatment of Gram-
negative infections, but it was withdrawn due to its nephrotoxicity. However, colistin has …