Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

Zebrafish (Danio rerio) are widely used as vertebrate model in developmental genetics and
functional genomics as well as in cardiac structure-function studies. The zebrafish heart has …

The sarcoplasmic reticulum (SR) is crucial for contraction and relaxation of the mammalian
cardiomyocyte, but its role in other vertebrate classes is equivocal. Recent evidence …

Both, the decreased L-type Ca2+ current (ICa, L) density and increased spontaneous Ca2+
release from the sarcoplasmic reticulum (SR), have been associated with atrial fibrillation …

The cardiac pacemaker sets the heart's primary rate, with pacemaker discharge controlled
by the autonomic nervous system through intracardiac ganglia. A fundamental issue in …

Adult zebrafish is an emerging vertebrate model for studying genetic basis of
cardiomyopathies; but whether the simple fish heart can model essential features of …

Sudden cardiac death is a leading cause of death worldwide, mainly caused by highly
disturbed electrical activation patterns in the heart. Currently, murine models are the most …

The zebrafish (Danio rerio) has emerged as an important model for developmental
cardiovascular (CV) biology; however, little is known about the cardiac function of the adult …

Cardiac excitation originates in the sinoatrial node (SAN), due to the automaticity of this
distinct region of the heart. SAN automaticity is the result of a gradual depolarisation of the …

Zebrafish are increasingly used as a vertebrate model to study human cardiovascular
disorders. Although heart structure and function are readily visualized in zebrafish embryos …