Advances in tissue engineering and innovative fabrication techniques for 3-D-structures: translational applications in neurodegenerative diseases

F Rey, B Barzaghini, A Nardini, M Bordoni, GV Zuccotti… - Cells, 2020 - mdpi.com
In the field of regenerative medicine applied to neurodegenerative diseases, one of the most
important challenges is the obtainment of innovative scaffolds aimed at improving the …

Hydrogel-based local drug delivery strategies for spinal cord repair

RB Shultz, Y Zhong - Neural regeneration research, 2021 - journals.lww.com
Spinal cord injury results in significant loss of motor, sensory, and autonomic functions.
Although a wide range of therapeutic agents have been shown to attenuate secondary injury …

Design and translation of injectable biomaterials

M Nguyen, M Karkanitsa, KL Christman - Nature Reviews …, 2024 - nature.com
Injectable biomaterials, including bulk materials and particulate materials, can be delivered
in a minimally invasive way and may provide alternative treatment options for conditions that …

Stroke studies in large animals: Prospects of mitochondrial transplantation and enhancing efficiency using hydrogels and nanoparticle-assisted delivery

O Ulger, I Eş, CM Proctor, O Algin - Ageing Research Reviews, 2024 - Elsevier
One of the most frequent reasons of mortality and disability today is acute ischemic stroke,
which occurs by an abrupt disruption of cerebral circulation. The intricate damage …

Methacrylated gellan gum and hyaluronic acid hydrogel blends for image-guided neurointerventions

S Vieira, P Strymecka, L Stanaszek… - Journal of materials …, 2020 - pubs.rsc.org
Cell-based therapies delivered via intrathecal injection are considered as one of the most
promising solutions for the treatment of amyotrophic lateral sclerosis (ALS). Herein …

Advances in bioinks and in vivo imaging of biomaterials for CNS applications

EP Oliveira, I Malysz-Cymborska, D Golubczyk… - Acta biomaterialia, 2019 - Elsevier
Due to increasing life expectancy incidence of neurological disorders is rapidly rising, thus
adding urgency to develop effective strategies for treatment. Stem cell-based therapies were …

The role of glia in canine degenerative myelopathy: relevance to human amyotrophic lateral sclerosis

D Golubczyk, I Malysz-Cymborska, L Kalkowski… - Molecular …, 2019 - Springer
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
progressive degeneration of motor neurons and grim prognosis. Over the last decade …

A perspective on therapies for amyotrophic lateral sclerosis: can disease progression be curbed?

X Xu, D Shen, Y Gao, Q Zhou, Y Ni, H Meng… - Translational …, 2021 - Springer
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease involving
both upper and lower motor neurons, leading to paralysis and eventually death …

[HTML][HTML] Chemobrain as a product of growing success in chemotherapy-focus on glia as both a victim and a cure

P Walczak, M Janowski - Neuropsychiatry, 2019 - ncbi.nlm.nih.gov
Chemotherapy-induced cognitive impairment or chemobrain is a frequent consequence of
cancer treatment with many psychiatric features. Ironically, the increasing efficacy of …

Two in one: use of divalent manganese ions as both cross-linking and MRI contrast agent for intrathecal injection of hydrogel-embedded stem cells

L Kalkowski, D Golubczyk, J Kwiatkowska, P Holak… - Pharmaceutics, 2021 - mdpi.com
Cell therapy is a promising tool for treating central nervous system (CNS) disorders; though,
the translational efforts are plagued by ineffective delivery methods. Due to the large contact …