Since the early days of foundational studies of nucleic acids, many chemical moieties have
been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one …

Abstract N 6-Methyladenosine (m6A) is one of the most abundant modifications of the
epitranscriptome and is found in cellular RNAs across all kingdoms of life. Advances in …

The mechanistic target of rapamycin complex 1 (mTORC1) regulates metabolism and cell
growth in response to nutrient, growth, and oncogenic signals. We found that mTORC1 …

N6 methylation at adenosine 1832 (m 6 A1832) of mammalian 18S rRNA, occupying a
critical position within the decoding center, is modified by a conserved methyltransferase …

The conceptual origins of ribosome specialization can be traced back to the earliest days of
molecular biology. Yet, this field has only recently begun to gather momentum, with …

Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression.
While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications …

Local adaptation to climate is common in plant species and has been studied in a range of
contexts, from improving crop yields to predicting population maladaptation to future …

Cellular stress is an intrinsic part of cell physiology that underlines cell survival or death. The
ability of mammalian cells to regulate global protein synthesis (aka translational control) …

Heritable non-genetic information can regulate a variety of complex phenotypes. However,
what specific non-genetic cues are transmitted from parents to their descendants are poorly …

Ribosomal RNAs (rRNAs) have long been known to carry chemical modifications, including
2′ O-methylation, pseudouridylation, N 6-methyladenosine (m 6 A), and N 6, 6 …