Abstract Tumor Necrosis Factor (TNF), initially known for its tumor cytotoxicity, is a potent
mediator of inflammation, as well as many normal physiological functions in homeostasis …

The human immune system involves highly complex and coordinated processes in which
small proteins named cytokines play a key role. Cytokines have been implicated in the …

During the past 30 years, elucidation of the pathogenesis of rheumatoid arthritis, Crohn's
disease, psoriasis, psoriatic arthritis and ankylosing spondylitis at the cellular and molecular …

In the last few decades, the AIDS pandemic and the significant advances in the medical
management of individuals with neoplastic and inflammatory conditions have resulted in a …

Biological agents have dramatically improved treatment options for patients with severe
psoriasis. Etanercept (tumor necrosis factor [TNF] receptor–immunoglobulin fusion protein) …

Importance Tumor necrosis factor (TNF) inhibitors are common therapies for certain
autoimmune diseases, such as rheumatoid arthritis. An association between TNF inhibitor …

Tumor necrosis factor-alpha (TNF-α) is a pleiotropic immune cytokine that belongs to the
TNF superfamily of receptor ligands. The cytokine exists as either a transmembrane or a …

Millions of people around the world suffer from psychiatric illnesses, causing unbearable
burden and immense distress to patients and their families. Accumulating evidence …

Results from clinical trials of biologic anti-TNF drugs performed in the late 1990s confirmed
the biological relevance of TNF function in the pathogenesis of chronic noninfectious …

Tumor necrosis factor α (TNF-α) blockade has emerged as a useful therapy for collagen
vascular diseases or graft-vs-host disease. Fungal infections complicating such therapy …