Glycosaminoglycans (GAGs) are a heterogeneous family of linear polysaccharides which
are composed of a repeating disaccharide unit. They are also linked to core proteins to form …

Solid cancers such as breast tumors comprise a collection of tumor, stromal and immune
cells, embedded within a network of tumor-specific extracellular matrix. This matrix is …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

It has long been found that hyaluronidases exist in a variety of organisms, playing their roles
in various biological processes including infection, envenomation and metabolic regulation …

The functional complexity of higher organisms is not easily accounted for by the size of their
genomes. Rather, complexity appears to be generated by transcriptional, translational, and …

Cancer is a serious health problem with a high mortality rate worldwide. Given the relevance
of mitochondria in numerous physiological and pathological mechanisms, such as …

Glycosaminoglycans (GAGs) are an important component of the tumor microenvironment
(TME). GAGs can interact with a variety of binding partners and thereby influence cancer …

Although tumor models have revolutionized perspectives on cancer aetiology and treatment,
current cell culture methods remain challenges in constructing organotypic tumor with in vivo …

BACKGROUND Hyaluronan (HA), an extracellular matrix glycosaminoglycan, has been
implicated in the pathophysiology of COVID-19 infection, pulmonary hypertension …

Over the last few decades, scientists have recognized the critical role that various
components of the extracellular matrix (ECM) play in maintaining homeostatic immunity …