Designing multi-target-directed flavonoids: a strategic approach to Alzheimer's disease
The underlying causes of Alzheimer's disease (AD) remain a mystery, with multiple
pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and …
pathological components, including oxidative stress, acetylcholinesterase, amyloid-β, and …
Synthesis of (E)‐α,β‐Unsaturated Thioesters from Malonic Acid Half Thioesters and Aldehydes
S Kawasaki, K Akagawa, K Kudo - Advanced Synthesis & …, 2023 - Wiley Online Library
A decarboxylative condensation of malonic acid half thioesters (MAHTs) with aldehydes
catalyzed by benzylammonium trifluoroacetate has been developed for the synthesis of (E) …
catalyzed by benzylammonium trifluoroacetate has been developed for the synthesis of (E) …
Discovering Effective Chiral Dipeptides against Aβ (1–42) Aggregation by the Computational Screening Strategy
W Shi, J Zhang, Z Wang, W Wang, X Peng… - ACS Chemical …, 2024 - ACS Publications
The β-sheet-breaker (BSB) peptides inhibiting amyloidogenic aggregation have been
extensively studied. However, the inhibition efficacy of ultrashort chiral dipeptides remains …
extensively studied. However, the inhibition efficacy of ultrashort chiral dipeptides remains …
Effect of Meroterpenoids from Sargassum macrocarpum on the Inhibition of Amyloid Polypeptide Aggregation
Y Tozawa, S Shinoda, M Sekiguchi… - Biological and …, 2024 - jstage.jst.go.jp
Amyloid polypeptide aggregation is considered one of the factors involved in the
pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), and the number of …
pathogenesis of Alzheimer's disease (AD) and type 2 diabetes (T2D), and the number of …
Synthesis of Symmetrical and Unsymmetrical Tetrahydroxybiphenyls and their Evaluation as Amyloid-β Aggregation Inhibitors
SL Wicks, JA Roberts, MJ Hurtt… - Letters in Organic …, 2024 - benthamdirect.com
Our group recently reported that the polyhydroxy aromatic compound 3, 3′, 4, 4′-
biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation …
biphenyltetrol (2a) is a successful inhibitor of amyloid-β peptide (Aβ) aggregation …
[PDF][PDF] L'attività di ricerca insignita del “Premio Divisione di Chimica Farmaceutica per la miglior tesi di Dottorato” ha riguardato lo sviluppo di piccole molecole bioattive …
F Basagni - soc.chim.it
63 LA CHIMICA E L'INDUSTRIA online| ANNO VII| N 1| GENNAIO/FEBBRAIO 2023
combinare l'inibizione dell'aggregazione di β-amiloide (Aβ, responsabile della formazione di …
combinare l'inibizione dell'aggregazione di β-amiloide (Aβ, responsabile della formazione di …