Inflammasomes are intracellular multiprotein signaling platforms that initiate inflammatory
responses in response to pathogens and cellular damage. Active inflammasomes induce …

RA is a complex disease that develops as a series of events often referred to as disease
continuum. RA would benefit from novel biomarker development for diagnosis where new …

The IL-1 superfamily of cytokines is a central regulator of immunity and inflammation. The
family is composed of 11 cytokines (with agonist, antagonist, and anti-inflammatory …

Ankylosing spondylitis (AS) is a chronic, inflammatory, rheumatological disease affecting
primarily the sacroiliac joint and vertebral column, with an etiology that remains obscure …

Objective: To characterise the immunohistological features of sacroiliitis in ankylosing
spondylitis (AS) at different disease stages. Methods: Biopsy samples from sacroiliac joints …

Objective: To determine the efficacy of anakinra, an interleukin 1 receptor antagonist in
active ankylosing spondylitis (AS), and to investigate the effect of anakinra treatment on …

Ankylosing spondylitis (AS), the prototypic seronegative arthropathy, is known to be highly
heritable, with> 90% of the risk of developing the disease determined genetically. As with …

Summary The Interleukin 1 (IL‐1) family plays a central role in the generation and regulation
of inflammatory responses, in both innate and adaptive immunity. Although the IL‐1 …

Ankylosing spondylitis (AS) is a common and highly heritable inflammatory arthropathy.
Although the gene HLA-B27 is almost essential for the inheritance of the condition, it alone …

Objective: To investigate changes in the levels of circulating cytokines with a focus on the
Th1/Th2 balance during and after pregnancy in patients with rheumatoid arthritis (RA) …