The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many
cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer …

Lung cancer is the leading cause of death by cancer in North America. A decade ago,
genomic rearrangements in the anaplastic lymphoma kinase (ALK) receptor tyrosine kinase …

Tyrosine kinases are involved in the pathogenesis of most cancers. However, few tyrosine
kinases have been shown to have a well-defined pathogenetic role in lymphomas. The …

RTKs (receptor tyrosine kinases) play important roles in cellular proliferation and
differentiation. In addition, RTKs reveal oncogenic potential when their kinase activities are …

The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies …

Anaplastic lymphoma kinase (ALK), a receptor tyrosine kinase in the insulin receptor
superfamily, was initially identified in constitutively activated oncogenic fusion forms–the …

Aberrant activation of anaplastic lymphoma kinase (ALK) has been described in a range of
human cancers, including non-small cell lung cancer and neuroblastoma. Vertebrate ALK …

Receptor tyrosine kinases (RTKs) are a class of cell surface receptors that, upon ligand
binding, stimulate a variety of critical cellular functions. The orphan receptor anaplastic …

Anaplastic lymphoma kinase (ALK) is a receptor-type protein tyrosine kinase that is currently
the focus of much attention in oncology. ALK is rendered oncogenic as a result of its fusion …

Despite improvements in cancer therapies in the past 50 years, neuroblastoma remains a
devastating clinical problem and a leading cause of childhood cancer deaths. Advances in …