[HTML][HTML] Red blood cell storage lesion: causes and potential clinical consequences

T Yoshida, M Prudent, A D'Alessandro - Blood Transfusion, 2019 - ncbi.nlm.nih.gov
Red blood cells (RBCs) are a specialised organ that enabled the evolution of multicellular
organisms by supplying a sufficient quantity of oxygen to cells that cannot obtain oxygen …

Extracellular vesicles in cancer: exosomes, microvesicles and the emerging role of large oncosomes

VR Minciacchi, MR Freeman, D Di Vizio - Seminars in cell & developmental …, 2015 - Elsevier
Since their first description, extracellular vesicles (EVs) have been the topic of avid study in a
variety of physiologic contexts and are now thought to play an important role in cancer. The …

Applying extracellular vesicles based therapeutics in clinical trials–an ISEV position paper

T Lener, M Gimona, L Aigner, V Börger… - Journal of …, 2015 - Taylor & Francis
Extracellular vesicles (EVs), such as exosomes and microvesicles, are released by different
cell types and participate in physiological and pathophysiological processes. EVs mediate …

[HTML][HTML] Exosomes derived from natural killer cells exert therapeutic effect in melanoma

L Zhu, S Kalimuthu, P Gangadaran, JM Oh, HW Lee… - Theranostics, 2017 - ncbi.nlm.nih.gov
Objective: Exosomes are nanovesicles that are released from normal and tumor cells and
are detectable in cell culture supernatant and human biological fluids. Although previous …

Exosomes as smart drug delivery vehicles for cancer immunotherapy

H Zhang, S Wang, M Sun, Y Cui, J Xing… - Frontiers in …, 2023 - frontiersin.org
Exosomes (Exos) as drug delivery vehicles have been widely used for cancer
immunotherapy owing to their good biocompatibility, low toxicity, and low immunogenicity …

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

V Huber, V Vallacchi, V Fleming, X Hu… - The Journal of …, 2018 - Am Soc Clin Investig
The accrual of myeloid-derived suppressor cells (MDSCs) represents a major obstacle to
effective immunotherapy in cancer patients, but the mechanisms underlying this process in …

Extracellular vesicles from red blood cells and their evolving roles in health, coagulopathy and therapy

K Thangaraju, SN Neerukonda, U Katneni… - International journal of …, 2020 - mdpi.com
Red blood cells (RBCs) release extracellular vesicles (EVs) including both endosome-
derived exosomes and plasma-membrane-derived microvesicles (MVs). RBC-derived EVs …

Donor dendritic cell–derived exosomes promote allograft-targeting immune response

Q Liu, DM Rojas-Canales, SJ Divito… - The Journal of …, 2016 - Am Soc Clin Investig
The immune response against transplanted allografts is one of the most potent reactions
mounted by the immune system. The acute rejection response has been attributed to donor …

Mechanisms of red blood cell transfusion‐related immunomodulation

KE Remy, MW Hall, J Cholette, NP Juffermans… - …, 2018 - Wiley Online Library
Red blood cell (RBC) transfusion is common in critically ill, postsurgical, and posttrauma
patients in whom both systemic inflammation and immune suppression are associated with …

Isolation of extracellular vesicles: Determining the correct approach

R Szatanek, J Baran, M Siedlar… - International …, 2015 - spandidos-publications.com
The discovery of extracellular vesicles (EVs) has revised the interpretation of intercellular
communication. It is now well established that EVs play a significant role in coagulation …