β-Defensins: farming the microbiome for homeostasis and health

KG Meade, C O'Farrelly - Frontiers in Immunology, 2019 - frontiersin.org
Diverse commensal populations are now regarded as key to physiological homeostasis and
protection against disease. Although bacteria are the most abundant component of …

Functions of antimicrobial peptides in vertebrates

E Edilia Avila - Current Protein and Peptide Science, 2017 - ingentaconnect.com
Objective: The aim of this review is to examine the multiple activities of antimicrobial
peptides (AMPs) in vertebrates. Content: The largest AMP families are the cathelicidins and …

Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle

B Fernandez-Fuertes, F Narciandi… - Biology of …, 2016 - academic.oup.com
Abstract Bovine beta-defensin 126 (BBD126) exhibits preferential expression for the cauda
epididymis of males, where it is absorbed onto the tail and postacrosomal region of the …

Unusual interplay of contrasting selective pressures on β-defensin genes implicated in male fertility of the Buffalo (Bubalus bubalis)

V Batra, A Maheshwarappa, K Dagar, S Kumar… - BMC evolutionary …, 2019 - Springer
Background The buffalo, despite its superior milk-producing ability, suffers from reproductive
limitations that constrain its lifetime productivity. Male sub-fertility, manifested as low …

Beta-defensins as marker for male fertility: a comprehensive review

S Solanki, V Kumar, P Kashyap, R Kumar… - Biology of …, 2023 - academic.oup.com
Bovine male fertility in animals has a direct impact on the productivity of dairy herds. The
epididymal sperm maturations involve extensive sperm surface modifications to gain the …

The biological mechanisms regulating sperm selection by the ovine cervix

S Fair, KG Meade, K Reynaud, X Druart… - …, 2019 - rep.bioscientifica.com
In species where semen is deposited in the vagina, the cervix has the unique function of
facilitating progress of spermatozoa towards the site of fertilisation while also preventing the …

Comparative genomic identification and validation of β-defensin genes in the Ovis aries genome

TJ Hall, C McQuillan, EK Finlay, C O'Farrelly, S Fair… - BMC genomics, 2017 - Springer
Background β-defensins are small, cationic, antimicrobial peptides found in species across
the plant and animal kingdoms. In addition to microbiocidal activity, roles in immunity as well …

Recombinant β-defensin 126 promotes bull sperm binding to bovine oviductal epithelia

A Lyons, F Narciandi, E Donnellan… - Reproduction …, 2018 - CSIRO Publishing
Primate β-defensin 126 regulates the ability of spermatozoa to bind to oviductal epithelial
cells in vitro. Bovine β-defensin 126 (BBD126) exhibits preferential expression in the cauda …

Analysis of amplification and association polymorphisms in the bovine beta-defensin 129 (BBD129) gene revealed its function in bull fertility

S Solanki, P Kashyap, SA Ali, V Kumar, A Vats… - Scientific Reports, 2022 - nature.com
Abstract β-defensins are adsorbable on the sperm surface in the male reproductive tract
(MRT) and enhance sperm functional characteristics. The beta-defensin 129 (DEFB129) …

[HTML][HTML] Characterisation of defensins across the marsupial family tree

E Peel, C Hogg, K Belov - Developmental & Comparative Immunology, 2024 - Elsevier
Defensins are antimicrobial peptides involved in innate immunity, and gene number differs
amongst eutherian mammals. Few studies have investigated defensins in marsupials …