Pelvic organ prolapse (POP) is a benign disease characterized by the descent of pelvic
organs due to weakened pelvic floor muscles and fascial tissues. Primarily affecting elderly …

Background Pelvic floor stability is influenced by various biomechanical, anatomical, and
physiological factors. Understanding these dynamics is crucial for improving the treatment of …

Pelvic organ prolapse (POP) has a high incidence rate among Chinese women. Repeated
mechanical stimulation is an important factor causing POP, but the injury mechanism has not …

This study delves into the role of FBLN5 in pelvic organ prolapse (POP) and its molecular
mechanisms, focusing on the FOSL1/miR-222/MEIS1/COL3A1 axis. Gene relationships …

The vagina is a viscoelastic fibromuscular organ that provides support to the pelvic organs.
The viscoelastic properties of the vagina are understudied but may be critical for pelvic …

Background Stem-cell-derived therapy is a promising option for tissue regeneration. Human
iPSC-derived progenitors of smooth muscle cells (pSMCs) exhibit limited proliferation and …

The biomechanical properties of the vagina are crucial to fulfilling physiological functions
such as menstruation, sexual intercourse, pregnancy, and childbirth. Alterations to these …

Pelvic organ prolapse (POP) is a gynecological disorder described by the descent of
superior pelvic organs into or out of the vagina as a consequence of disrupted muscles and …

The specific anatomy, physiology, and health needs of women have long been overlooked
and understudied, with the male body and biology centered as the 'baseline'in biomedical …

Higher reproductive age is associated with an increased risk of gestational diabetes, pre-
eclampsia, and severe vaginal tearing during delivery. Further, menopause is associated …