Roadmap: proton therapy physics and biology

H Paganetti, C Beltran, S Both, L Dong… - Physics in Medicine …, 2021 - iopscience.iop.org
The treatment of cancer with proton radiation therapy was first suggested in 1946 followed
by the first treatments in the 1950s. As of 2020, almost 200 000 patients have been treated …

[HTML][HTML] Technical challenges for FLASH proton therapy

S Jolly, H Owen, M Schippers, C Welsch - Physica Medica, 2020 - Elsevier
There is growing interest in the radiotherapy community in the application of FLASH
radiotherapy, wherein the dose is delivered to the entire treatment volume in less than a …

Future developments in charged particle therapy: improving beam delivery for efficiency and efficacy

J Yap, A De Franco, S Sheehy - Frontiers in Oncology, 2021 - frontiersin.org
The physical and clinical benefits of charged particle therapy (CPT) are well recognized.
However, the availability of CPT and complete exploitation of dosimetric advantages are still …

Ultra‐high dose rate radiation production and delivery systems intended for FLASH

J Farr, V Grilj, V Malka, S Sudharsan… - Medical …, 2022 - Wiley Online Library
Higher dose rates, a trend for radiotherapy machines, can be beneficial in shortening
treatment times for radiosurgery and mitigating the effects of motion. Recently, even higher …

Design and test of a curved superconducting dipole magnet for proton therapy

L Brouwer, S Caspi, K Edwards, A Godeke… - Nuclear Instruments and …, 2020 - Elsevier
We report on the design and test of a curved superconducting magnet completed as part of a
collaborative project between Lawrence Berkeley National Laboratory, the Paul Scherrer …

Flash irradiation with proton beams: beam characteristics and their implications for beam diagnostics

KP Nesteruk, S Psoroulas - applied sciences, 2021 - mdpi.com
FLASH irradiations use dose-rates orders of magnitude higher than commonly used in
patient treatments. Such irradiations have shown interesting normal tissue sparing in cell …

Improving delivery efficiency using spots and energy layers reduction algorithms based on a large momentum acceptance beamline

W Wang, X Liu, Z Yang, Y Liao, P Li, R Zhao… - Medical …, 2023 - Wiley Online Library
Background Intensity‐modulated proton therapy (IMPT) is a well‐known delivery method of
proton therapy. Besides higher plan quality, reducing the delivery time is also essential to …

Exploring beamline momentum acceptance for tracking respiratory variability in lung cancer proton therapy: a simulation study

AC Giovannelli, A Köthe, S Safai, D Meer… - Physics in Medicine …, 2023 - iopscience.iop.org
Objective. Investigating the aspects of proton beam delivery to track organ motion with pencil
beam scanning therapy. Considering current systems as a reference, specify requirements …

Beam properties within the momentum acceptance of a clinical gantry beamline for proton therapy

AC Giovannelli, V Maradia, D Meer, S Safai… - Medical …, 2022 - Wiley Online Library
Purpose Energy changes in pencil beam scanning proton therapy can be a limiting factor in
delivery time, hence, limiting patient throughput and the effectiveness of motion mitigation …

Neutron dosimetry and shielding verification in commissioning of Compact Proton Therapy Centers (CPTC) using MCNP6. 2 Monte Carlo code

GF Garcia-Fernandez, E Gallego… - Applied Radiation and …, 2021 - Elsevier
Proton therapy (PT) is an external radiotherapy using proton beams with energies between
70 and 230 MeV to treat some type of tumours with outstanding benefits, due to its energy …