Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …

Protein lysine methylation is a crucial post-translational modification that regulates the
functions of both histone and non-histone proteins. Deregulation of the enzymes or 'writers' …

METTL16 has recently been identified as an RNA methyltransferase responsible for the
deposition of N 6-methyladenosine (m6A) in a few transcripts. Whether METTL16 methylates …

Cancer cells selectively promote translation of specific oncogenic transcripts to facilitate
cancer survival and progression, but the underlying mechanisms are poorly understood …

Abstract N6-methyladenosine (m6A), and its reader protein YTHDF1, play a pivotal role in
human tumorigenesis by affecting nearly every stage of RNA metabolism. Autophagy …

Abstract N 6-Methyladenosine (m6A) is the most abundant RNA modification in mammal
mRNAs and increasing evidence suggests the key roles of m6A in human tumorigenesis …

Summary Cyclic GMP-AMP synthase (cGAS) is the major sensor for cytosolic DNA and
activates type I interferon signaling and plays an essential role in antitumor immunity …

RNA modification has recently become a significant process of gene regulation, and the
methyltransferase-like (METTL) family of proteins plays a critical role in RNA modification …

Histone methyltransferases of the nuclear receptor-binding SET domain protein (NSD)
family, including NSD1, NSD2 and NSD3, have crucial roles in chromatin regulation and are …

Amplification of chromosomal region 8p11–12 is a common genetic alteration that has been
implicated in the aetiology of lung squamous cell carcinoma (LUSC),–. The FGFR1 gene is …