Cell death is a process consequential to cerebral ischemia and cerebral
ischemia/reperfusion (I/R) injury. Recent evidence suggest that necroptosis has been …

Over the past few decades, mechanisms of programmed cell death have attracted the
scientific community because they are involved in diverse human diseases. Initially …

Neuronal death and inflammatory response are two common pathological hallmarks of
acute central nervous system injury and chronic degenerative disorders, both of which are …

Ischemic disease is among the deadliest and most disabling illnesses. Prominent examples
include myocardial infarction and stroke. Most, if not all, underlying pathological changes …

Alzheimer's disease (AD) is an intractable neurodegenerative disease showing a clinical
manifestation with memory loss, cognitive impairment and behavioral dysfunction. The …

Necroptosis, a regulated form of cell death, is involved in the genesis and development of
various life-threatening diseases, including cancer, neurological disorders, cardiac …

This work reports on a complex in silico assessment of the ADME properties of Salubrinal
(S1) and 54 of its structural analogues containing a cinnamic acid residue (S2–S40) or a …

Traumatic brain injury (TBI) is a dominant cause of death and permanent disability
worldwide. Although TBI could significantly increase the proliferation of adult neural stem …

Since its discovery in the 1960 s, doxorubicin (DOX) has constantly elicited the broadest
spectrum of cancerocidal activity against human cancers. However, cardiotoxicity caused by …

Cadmium (Cd) and excess molybdenum (Mo) pose serious threats to animal health. Our
previous study has determined that Cd and/or Mo exposure can cause ovarian damage of …