On the expansion of biological functions of lytic polysaccharide monooxygenases

TM Vandhana, JL Reyre, D Sushmaa… - New …, 2022 - Wiley Online Library
Lytic polysaccharide monooxygenases (LPMOs) constitute an enigmatic class of enzymes,
the discovery of which has opened up a new arena of riveting research. LPMOs can …

Expanding the catalytic landscape of metalloenzymes with lytic polysaccharide monooxygenases

A Munzone, VGH Eijsink, JG Berrin… - Nature Reviews …, 2024 - nature.com
Lytic polysaccharide monooxygenases (LPMOs) have an essential role in global carbon
cycle, industrial biomass processing and microbial pathogenicity by catalysing the oxidative …

Unraveling the valence state and reactivity of copper centers in membrane-bound particulate methane monooxygenase

W Peng, Z Wang, Q Zhang, S Yan… - Journal of the American …, 2023 - ACS Publications
Particulate methane monooxygenase (pMMO) plays a critical role in catalyzing the
conversion of methane to methanol, constituting the initial step in the C1 metabolic pathway …

Deciphering the oxygen activation mechanism at the CuC site of particulate methane monooxygenase

W Peng, X Qu, S Shaik, B Wang - Nature Catalysis, 2021 - nature.com
The enzymatic oxidation of methane to methanol was discovered in methanotrophs over 110
years ago. Nevertheless, the mechanism of action of particulate methane monooxygenase …

Cryptococcus extracellular vesicles properties and their use as vaccine platforms

J Rizzo, SSW Wong, AD Gazi… - Journal of …, 2021 - Wiley Online Library
Whereas extracellular vesicle (EV) research has become commonplace in different
biomedical fields, this field of research is still in its infancy in mycology. Here we provide a …

AA16 Oxidoreductases Boost Cellulose-Active AA9 Lytic Polysaccharide Monooxygenases from Myceliophthora thermophila

P Sun, Z Huang, S Banerjee, MAS Kadowaki… - ACS …, 2023 - ACS Publications
Copper-dependent lytic polysaccharide monooxygenases (LPMOs) classified in Auxiliary
Activity (AA) families are considered indispensable as synergistic partners for cellulolytic …

The lytic polysaccharide monooxygenase CbpD promotes Pseudomonas aeruginosa virulence in systemic infection

F Askarian, S Uchiyama, H Masson… - Nature …, 2021 - nature.com
The recently discovered lytic polysaccharide monooxygenases (LPMOs), which cleave
polysaccharides by oxidation, have been associated with bacterial virulence, but supporting …

Copper regulates the host innate immune response against bacterial infection via activation of ALPK1 kinase

J Lu, X Liu, X Li, H Li, L Shi, X Xia… - Proceedings of the …, 2024 - National Acad Sciences
Copper is an essential trace element for the human body, and its requirement for optimistic
immune functions has been recognized for decades. How copper is involved in the innate …

Gene family expansions and transcriptome signatures uncover fungal adaptations to wood decay

H Hage, S Miyauchi, M Virágh, E Drula… - Environmental …, 2021 - Wiley Online Library
Because they comprise some of the most efficient wood‐decayers, Polyporales fungi impact
carbon cycling in forest environment. Despite continuous discoveries on the enzymatic …

Lytic polysaccharide monooxygenases and other histidine-brace copper proteins: structure, oxygen activation and biotechnological applications

JØ Ipsen, M Hallas-Møller, S Brander… - Biochemical Society …, 2021 - portlandpress.com
Lytic polysaccharide monooxygenases (LPMOs) are mononuclear copper enzymes that
catalyse the oxidative cleavage of glycosidic bonds. They are characterised by two histidine …