Abstract The Mitogen Activated Protein Kinase (MAPK) signaling plays a critical role in the
outcome and the sensitivity to anticancer therapies. Activated MAPK can transmit …

Autophagy refers to a lysosomal degradative pathway or a process of self-cannibalization.
This pathway maintains nutrients levels for vital cellular functions during periods of …

Apoptosis is a primary characteristic in the pathogenesis of liver disease. Hepatic apoptosis
is regulated by autophagic activity. However, mechanisms mediating their interaction remain …

Cancer is a heterogeneous disease and one of the major issues of health concern,
especially for the public health system globally. Nature is a source of anticancer drugs with …

Hepatocellular carcinoma (HCC) contains a subset of cancer stem cells (CSC) that cause
tumor recurrence, metastasis, and chemical resistance. Histone deacetylase 11 (HDAC11) …

Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …

Cell death is a natural biological process that occurs in living organisms. Since 1963,
extensive research has shed light on the occurrence, progress, and final outcome of cell …

Autophagy fights against harmful stimuli and degrades cytosolic macromolecules,
organelles, and intracellular pathogens. Autophagy dysfunction is associated with many …

Autophagy is a catabolic process by which eukaryotic cells eliminate cytosolic materials
through vacuole-mediated sequestration and subsequent delivery to lysosomes for …

Long noncoding RNAs (lncRNAs) have been identified to play increasingly important roles
in tumorigenesis, and they may serve as novel biomarkers for cancer therapy. LncRNA …