Glutamate is the primary excitatory neurotransmitter of the brain. Cellular homeostasis of
glutamate is of paramount importance for normal brain function and relies on an intricate …

Astrocytes contribute to the complex cellular pathology of Alzheimer's disease (AD).
Neurons and astrocytes function in close collaboration through neurotransmitter recycling …

Multi‐omics usually refers to the crossover application of multiple high‐throughput screening
technologies represented by genomics, transcriptomics, single‐cell transcriptomics …

Microglia-mediated synaptic loss contributes to the development of cognitive impairments in
Alzheimer's disease (AD). However, the basis for this immune-mediated attack on synapses …

Nanoplastics are being detected with increasing frequency in aquatic environments.
Although evidence suggests that nanoplastics can cause overt toxicity to biota across …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

The role of brain cholesterol metabolism in Alzheimer's disease (AD) remains unclear.
Peripheral and brain cholesterol levels are largely independent due to the impermeability of …

Capillary electrophoresis‐mass spectrometry (CE‐MS) is now a mature analytical technique
in metabolomics, notably for the efficient profiling of polar and charged metabolites. Over the …

Glutamine is an essential cerebral metabolite. Several critical brain processes are directly
linked to glutamine, including ammonia homeostasis, energy metabolism and …

Alzheimer's disease (AD) is determined by various pathophysiological mechanisms starting
10–25 years before the onset of clinical symptoms. As multiple functionally interconnected …