In the mammalian central nervous system, excitatory glutamatergic synapses harness
neurotransmission that is mediated by ion flow through α-amino-3-hydroxy-5-methyl-4 …

The specificity of synapses in the mammalian brain cannot possibly be accounted for by one-
to-one biochemical matching. The alternative proposed in this article is that connections are …

Today, it is widely appreciated that protein–protein interactions play a fundamental role in
biological processes. This was not always the case. The study of protein interactions started …

The number of acetylcholine receptors was determined in the neuromuscular junctions of
eight patients with typical myasthenia gravis and in five controls, by means of 125I-labeled α …

5-Hydroxytryptamine is a powerful activator of some intestinal smooth muscle, which was
discovered first in extracts of gastric mucosa by Erspamer (405) and later, independently, in …

Binding sites with high affinity and specificity for [3H] quinuclidinyl benzilate (QNB) are
present in homogenates of rat brain. The characteristics of the binding sites resemble those …

Exposed sternomastoid muscles of anaesthetized mice were bathed in 125I-labeled α-
bungarotoxin until all neurally evoked muscle contractions were eliminated. The distribution …

Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor
(AChR) number and density at neuromuscular junctions in living adult mice. At fully …

The distribution and quantitation of (125) I-α-bungarotoxin (α-BTX) binding sites and thus
acetylcholine receptor (AChR) were determined in mouse sternomastoid muscle by electron …

We examined the role of nerve terminals in organizing acetylcholine receptors on
regenerating skeletal-muscle fibers. When muscle fibers are damaged, they degenerate and …