Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed
by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these …

Genomic and chromosomal instability are hallmarks of cancer and shape the genomic
composition of cancer cells, thereby determining their behavior and response to treatment …

Tumors initiate by mutations in cancer cells, and progress through interactions of the cancer
cells with non-malignant cells of the tumor microenvironment. Major players in the tumor …

Prostate cancer is a major cause of cancer morbidity and mortality. Intra-prostatic
inflammation is a risk factor for prostate carcinogenesis, with diet, chemical injury and an …

As our understanding of the mechanisms of cancer treatment has increased, a growing
number of studies demonstrate pathways through which DNA damage repair (DDR) affects …

Background B7-H3 is a cell surface immunomodulatory glycoprotein overexpressed in
prostate cancers (PCs). Understanding its longitudinal expression at emergence of …

The landscape of cancer treatment has been transformed over the past decade by the
success of immune-targeting therapies. However, despite sipuleucel-T being the first-ever …

Genomic instability and inflammation are intricately connected hallmark features of cancer.
DNA repair defects due to BRCA1/2 mutation instigate immune signaling through the …

Immunotherapeutic treatment approaches are now an integral part of the treatment of many
solid tumors. However, attempts to integrate immunotherapy into the treatment of prostate …

Background Characterization of tumor-related genetic alterations is promising for the
screening of new predictive markers in non-small cell lung cancer (NSCLC). Aim of the study …