The aggregation of proteins into amyloid-like fibrils is seen in many neurodegenerative
diseases. Recent years have seen much progress in our understanding of these misfolded …

UV resonance Raman (UVRR) spectroscopy is a powerful tool for investigating the structure
of biological molecules, such as proteins. Numerous UVRR spectroscopic markers that …

Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of
fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular …

The lack of detailed insight into the structure of aggregates formed by the huntingtin protein
(HTT) has hampered the efforts to develop therapeutics and diagnostics targeting pathology …

The outstanding potential of Extracellular Vesicles (EVs) in medicine, deserves a detailed
study of the molecular aspects regulating their incorporation into target cells. However …

Tauopathies are a group of disorders in which the deposition of abnormally folded tau
protein accompanies neurodegeneration. The development of methods for detection and …

Amyloids are protein aggregates with a specific filamentous structure that are related to a
number of human diseases, and also to some important physiological processes in animals …

It is well established that amyloid proteins play a primary role in neurodegenerative
diseases. Alzheimer's, Parkinson's, type II diabetes, and Creutzfeldt-Jakob's diseases are …

Neurodegeneration in Huntington's disease (HD) is accompanied by the aggregation of
fragments of the mutant huntingtin protein, a biomarker of disease progression. A particular …

In classical amyloidoses, amyloid fibres form through the nucleation and accretion of protein
monomers, with protofibrils and fibrils exhibiting a cross-β motif of parallel or antiparallel β …