Colorectal cancer is one of the most common cancers worldwide with high mortality. Distant
metastasis and relapse are major causes of patient death. Cancer stem cells (CSCs) play a …

Despite advances in treatment regimens that comprise surgery, chemotherapy, and
radiation, outcome of many brain tumors remains dismal, more so when they recur. The …

Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …

GBM is the most common primary brain tumor in adults, and the aggressive nature of this
tumor contributes to its extremely poor prognosis. Over the years, the heterogeneous and …

Natural killer (NK) cells are the key immune effectors with the ability to mediate selection and
differentiation of a number of different cancer stem cells/undifferentiated tumors via lysis, and …

Background Natural killer (NK) cells can recognize and kill cancer cells directly, but their
activity can be attenuated by various inhibitory molecules expressed on the surface. The …

Glioblastomas remain the most lethal primary brain tumors. Natural killer (NK) cell-based
therapy is a promising immunotherapeutic strategy in the treatment of glioblastomas, since …

Introduction: Standard cytoreductive cancer therapy, such as chemotherapy and
radiotherapy, are frequently resisted by a small portion of cancer cells with 'stem-cell'like …

The brain is considered an immune privileged site due to the high selectivity of the blood-
brain barrier which restricts the passage of molecules and cells into the brain parenchyma …

We have recently shown that natural killer (NK) cells select and differentiate cancer stem
cells (CSCs)/undifferentiated tumors via secreted and membrane bound IFN-gamma (IFN-γ) …