Exploiting blood-based biomarkers to align preclinical models with human traumatic brain injury

I Lisi, F Moro, E Mazzone, N Marklund, F Pischiutta… - Brain, 2024 - academic.oup.com
Rodent models are important research tools for studying the pathophysiology of traumatic
brain injury (TBI) and developing new therapeutic interventions for this devastating …

[HTML][HTML] Targeting NETosis in Acute Brain Injury: A Systematic Review of Preclinical and Clinical Evidence

M Savi, F Su, ED Sterchele, EG Bogossian, Z Demailly… - Cells, 2024 - mdpi.com
Acute brain injury (ABI) remains one of the leading causes of death and disability world-
wide. Its treatment is challenging due to the heterogeneity of the mechanisms involved and …

Murine traumatic brain injury model comparison: closed head injury versus controlled cortical impact

MR Baucom, AD Price, L England, RM Schuster… - Journal of surgical …, 2024 - Elsevier
Introduction Various murine models have been utilized to study TBI, including closed head
injury (CHI) and controlled cortical impact (CCI), without direct comparison. The aim of our …

On-field rule out of mild traumatic brain injury: can blood-based biomarker testing change outcome of major sporting events?

AHB Wu, WF Peacock - The Journal of Applied Laboratory …, 2024 - academic.oup.com
Background Mild traumatic brain injury (mTBI) is defined as a Glascow Coma Score of
between 13 and 15. The diagnosis and rule out of individuals suffering from mTBI on an …

Translating from mice to humans: using preclinical blood-based biomarkers for the prognosis and treatment of traumatic brain injury

I Lisi, F Moro, E Mazzone, N Marklund, F Pischiutta… - bioRxiv, 2023 - biorxiv.org
Rodent models are important research tools for studying the pathophysiology of traumatic
brain injury (TBI) and developing potential new therapeutic interventions for this devastating …