Metastasis remains a pivotal characteristic of cancer and is the primary contributor to cancer-
associated mortality. Despite its significance, the mechanisms governing metastasis are not …

During mammalian embryonic development, primary cilia transduce and regulate several
signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most …

The development of the nervous system relies on the coordinated regulation of stem cell self-
renewal and differentiation. The discovery that brain tumours contain a subpopulation of …

Most lncRNAs display species-specific expression patterns suggesting that animal models
of cancer may only incompletely recapitulate the regulatory crosstalk between lncRNAs and …

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum.
Although abnormal GABAergic receptor activation has been described in MB, studies have …

Abstract Treatment for medulloblastoma (MB)—the most common malignant pediatric brain
tumor—includes prophylactic radiation administered to the entire brain and spine due to the …

Abstract The Sonic Hedgehog (SHH) pathway is crucial regulator of embryonic development
and stemness. Its alteration leads to medulloblastoma (MB), the most common malignant …

Disruptions to developmental cell signaling pathways and transcriptional cascades have
been implicated in tumor initiation, maintenance and progression. Resurgence of aberrant …

Astrocytes, initially described as merely support cells, are now known as a heterogeneous
population of cells actively involved in a variety of biological functions such as: neuronal …

Purpose: Glioblastoma (GBM) is one of the most aggressive and lethal cancer types in
humans. The standard treatment approach is surgery followed by chemoradiation. However …