Modeling and simulation of genetic regulatory systems: a literature review

H De Jong - Journal of computational biology, 2002 - liebertpub.com
In order to understand the functioning of organisms on the molecular level, we need to know
which genes are expressed, when and where in the organism, and to which extent. The …

Modeling gene regulatory networks with piecewise linear differential equations

J Gebert, N Radde, GW Weber - European Journal of Operational Research, 2007 - Elsevier
Microarray chips generate large amounts of data about a cell's state. In our work we want to
analyze these data in order to describe the regulation processes within a cell. Therefore, we …

A perspective of synthetic biology: assembling building blocks for novel functions

P Fu - Biotechnology Journal: Healthcare Nutrition …, 2006 - Wiley Online Library
Synthetic biology is a recently emerging field that applies engineering formalisms to design
and construct new biological parts, devices, and systems for novel functions or life forms that …

Steerable filters for early vision, image analysis, and wavelet decomposition

WT Freeman, EH Adelson - Proceedings Third International …, 1990 - computer.org
Global level analyses of biological systems require the integration and interoperation of
various biological models. Such integration and interoperation are usually achieved using …

[PDF][PDF] Rate distortion manifolds as model spaces for cognitive information

JF Glazebrook, R Wallace - Informatica, 2009 - informatica.si
Rate Distortion Manifolds as Model Spaces for Cognitive Information 1 Introduction Page 1
Informatica 33 (2009) 309–345 309 Rate Distortion Manifolds as Model Spaces for …

Inferring gene regulatory networks from expression data

L Kaderali, N Radde - Computational intelligence in bioinformatics, 2008 - Springer
Gene regulatory networks describe how cells control the expression of genes, which,
together with some additional regulation further downstream, determines the production of …

Reconstructing nonlinear dynamic models of gene regulation using stochastic sampling

J Mazur, D Ritter, G Reinelt, L Kaderali - BMC bioinformatics, 2009 - Springer
Background The reconstruction of gene regulatory networks from time series gene
expression data is one of the most difficult problems in systems biology. This is due to …

[PDF][PDF] Qualitative simulation of genetic regulatory networks: Method and application

H De Jong, M Page, C Hernandez, J Geiselmann - IJCAI, 2001 - Citeseer
Computer modeling and simulation are indispensable for understanding the functioning of
an organism on a molecular level. We present an implemented method for the qualitative …

[HTML][HTML] Simulating complex intracellular processes using object-oriented computational modelling

CG Johnson, JP Goldman, WJ Gullick - Progress in biophysics and …, 2004 - Elsevier
The aim of this paper is to give an overview of computer modelling and simulation in cellular
biology, in particular as applied to complex biochemical processes within the cell. This is …

Complex non-linear biodynamics in categories, higher dimensional algebra and Łukasiewicz–Moisil topos: transformations of neuronal, genetic and neoplastic …

IC Baianu, R Brown, G Georgescu, JF Glazebrook - Axiomathes, 2006 - Springer
A categorical, higher dimensional algebra and generalized topos framework for Łukasiewicz–
Moisil Algebraic–Logic models of non-linear dynamics in complex functional genomes and …