The central mechanism involved in the pathogenesis of MAFLD is insulin resistance with
hyperinsulinemia, which stimulates triglyceride synthesis and accumulation in the liver. On …

The endocannabinoid system (ECS) and reactive oxygen species (ROS) constitute two key
cellular signalling systems that participate in the modulation of diverse cellular functions …

Over-activation of the endocannabinoid/CB 1 R system is a hallmark feature of obesity and
its related comorbidities, most notably type 2 diabetes (T2D), and non-alcoholic fatty liver …

Abstract Hepatic ischemia/reperfusion (HIR), which can result in severe liver injury and
dysfunction, is usually associated with autophagy and endocannabinoid system …

Maternal diet plays a critical role in health development. Perinatal overnutrition induces
metabolic dysfunctions and obesity in the offspring. Obesity is associated with …

The endocannabinoid system (ECS) is a key cellular signalling system that has been
implicated in the regulation of diverse cellular functions. Importantly, growing evidence …

The prevalence of obesity and obesity-related disorders such as type 2 diabetes (T2D) and
metabolic syndrome has increased significantly in the past decades, reaching epidemic …

Dysfunction of the endocannabinoid system (ES) has been identified in nonalcoholic fatty
liver disease (NAFLD) and associated metabolic disorders. Cannabinoid receptor type 1 …

Nonalcoholic fatty liver disease (NAFLD), as a multisystemic disease, is the most prevalent
chronic liver disease characterized by extremely complex pathogenic mechanisms and …

Purpose Maternal high-fat diet (HF) programs obesity, metabolic dysfunction-associated
steatotic liver disease (MASLD), hypertriglyceridemia, and hyperglycemia associated with …