[HTML][HTML] Interleukin 1α: a comprehensive review on the role of IL-1α in the pathogenesis and treatment of autoimmune and inflammatory diseases

G Cavalli, S Colafrancesco, G Emmi, M Imazio… - Autoimmunity …, 2021 - Elsevier
Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

[HTML][HTML] The role of Interleukin 6 inhibitors in therapy of severe COVID-19

E Nasonov, M Samsonov - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Cytokine storm syndrome (CSS) is a severe complication of inflammatory immune diseases
or treatment of malignancies; it may also appear during the progression of COVID-19. CSS …

American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated With SARS–CoV‐2 and hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2020 - Wiley Online Library
Objective To provide guidance on the management of multisystem inflammatory syndrome
in children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

American College of rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS–CoV‐2 and Hyperinflammation in …

LA Henderson, SW Canna, KG Friedman… - Arthritis & …, 2021 - Wiley Online Library
Objective To provide guidance on the management of Multisystem Inflammatory Syndrome
in Children (MIS‐C), a condition characterized by fever, inflammation, and multiorgan …

Proteomic blood profiling in mild, severe and critical COVID-19 patients

H Patel, NJ Ashton, RJB Dobson, LM Andersson… - Scientific reports, 2021 - nature.com
The recent SARS-CoV-2 pandemic manifests itself as a mild respiratory tract infection in
most individuals, leading to COVID-19 disease. However, in some infected individuals, this …

Haemophagocytic syndrome and COVID-19

S Retamozo, P Brito-Zerón, A Sisó-Almirall… - Clinical …, 2021 - Springer
Primary and secondary haemophagocytic lymphohistiocytosis (HLH) are hyperferritinaemic
hyperinflammatory syndromes with a common terminal pathway triggered by different …

[HTML][HTML] IL-1 receptor antagonist anakinra in the treatment of COVID-19 acute respiratory distress syndrome: a retrospective, observational study

M Franzetti, A Forastieri, N Borsa… - The Journal of …, 2021 - journals.aai.org
The IL-1 receptor antagonist, anakinra, may represent a therapeutic option for acute
respiratory distress syndrome (ARDS) associated with coronavirus disease 2019 (COVID …

Interleukin-1 in COVID-19 Infection: Immunopathogenesis and Possible Therapeutic Perspective

A Mardi, S Meidaninikjeh, S Nikfarjam… - Viral …, 2021 - liebertpub.com
The newfound coronavirus disease 2019 (COVID-19), initiated by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), is an international public health concern …

A propensity score-matched analysis of mortality in solid organ transplant patients with COVID-19 compared to non-solid organ transplant patients

L Linares, F Cofan, F Diekmann, S Herrera… - PLoS …, 2021 - journals.plos.org
In the context of COVID-19 pandemic, we aimed to analyze the epidemiology, clinical
characteristics, risk factors for mortality and impact of COVID-19 on outcomes of solid organ …

Anakinra for patients with COVID-19: a meta-analysis of non-randomized cohort studies.

L Pasin, G Cavalli, P Navalesi, N Sella… - European journal of …, 2021 - Elsevier
Introduction Severe COVID-19 cases have a detrimental hyper-inflammatory host response
and different cytokine-blocking biologic agents were explored to improve outcomes …