Increasing understanding of the pathogenesis of rheumatoid arthritis (RA) has remarkably
promoted the development of effective therapeutic regimens of RA. Nevertheless, the …

Rheumatoid arthritis (RA) is a classic autoimmune disease characterized by uncontrolled
synovial proliferation, pannus formation, cartilage injury, and bone destruction. The specific …

Offering up-to-date, comprehensive coverage of disease progression, diagnosis,
management, and prognosis, Textbook of Pediatric Rheumatology is the definitive reference …

Autoimmunity refers to the phenomenon that the body's immune system produces antibodies
or sensitized lymphocytes to its own tissues to cause an immune response. Immune …

Background MicroRNAs (miRNAs) are small non-coding RNAs which have been implicated
as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines …

Objectives: Oncostatin M (OSM), a pleiotropic cytokine and a member of the gp130/IL-6
cytokine family, has been implicated in the pathogenesis of autoimmune diseases. Here we …

Rheumatoid arthritis (RA) is a systemic autoimmune disease. Synovial hyperplasia and
persistent inflammation serve as its typical pathological manifestations, which ultimately lead …

Objectives We investigated the reciprocal relationship linking fibroblast-like synoviocytes
(FLS) and T lymphocytes in the inflamed RA synovium and subsequently targeted cellular …

Berberine (BBR) is the effective constituent of Cortex phellodendri and was characterized as
an excellent anti-microbial agent with significant anti-inflammatory effects. Previously, we …

Recent studies have shown the significance of metabolic reprogramming in immune and
stromal cell function. Yet, the metabolic reconfiguration of RA macrophages (MΦs) is …