Ubiquitin is a 76-amino acid regulatory protein involved in many important cellular
processes. Ubiquitin can be attached to other proteins at either a lysine residue or to the N …

Within mammalian systems, there exists enormous opportunity to use synthetic gene circuits
to enhance phenotype-based drug discovery, to map the molecular origins of disease, and …

Genetic engineering projects often require control over when a protein is degraded. To this
end, we use a fusion between a degron and an inactivating peptide that can be added to the …

Prokaryotic regulatory proteins respond to diverse signals and represent a rich resource for
building synthetic sensors and circuits. The TetR family contains> 105 members that use a …

Proteasomes are critical proteases in the cell responsible for the turnover of many
cytoplasmic and nuclear proteins. They are essential for many cellular processes and …

Ischemic stroke results in severe brain damage and remains one of the leading causes of
death and disability worldwide. Effective neuroprotective therapies are needed to reduce …

Protein function is typically studied and engineered by modulating protein levels within the
complex cellular environment. To achieve fast, targeted, and predictable control of cellular …

Abstract Alzheimer's disease (AD), and many neurodegenerative disorders, are
multifactorial in nature. They involve a combination of genomic, epigenomic, interactomic …

Optogenetic control of protein activity is a versatile technique to gain control over cellular
processes, for example, for biomedical and biotechnological applications. Among other …

Toxicology aims to comprehend and envisage the adverse outcomes of chemicals and
xenobiotics on the biological system. Predicting toxicity on the biological system is a …