Alzheimer's disease (AD) is the most common form of neurodegenerative disorder with
dementia, accounting for approximately 70% of the all cases. Currently, 5.8 million people in …

Exosomes are small extracellular vesicles released by almost all cell types in physiological
and pathological conditions. The exosomal potential to unravel disease mechanisms, or to …

Alzheimer disease (AD) is the most common form of age-related dementia. The etiology of
AD is considered to be multifactorial as only a negligible percentage of cases have a familial …

The amyloid β peptide (Aβ) is a critical initiator that triggers the progression of Alzheimer's
Disease (AD) via accumulation and aggregation, of which the process may be caused by Aβ …

Background Epidemiological and clinical evidence suggests that an increased intake of long-
chain n-3 fatty acids protects against mortality from coronary artery disease. We aimed to test …

The amyloid hypothesis has yielded a series of well-validated candidate drug targets with
potential for the treatment of Alzheimer disease (AD). Three proteases that are involved in …

The amyloid precursor protein (APP) undergoes constitutive shedding by a protease activity
called α‐secretase. This is considered an important mechanism preventing the generation of …

An important pathological feature of Alzheimer's disease (AD) is the presence of
extracellular senile plaques in the brain. Senile plaques are composed of aggregations of …

The ADAMs (a disintegrin and metalloproteinase) are a fascinating family of transmembrane
and secreted proteins with important roles in regulating cell phenotype via their effects on …

The β‐amyloid precursor protein (APP) has been extensively studied for its role as the
precursor of the β‐amyloid protein (Aβ) of Alzheimer's disease. However, the normal …