Background Cannabidiol (CBD), which is one major constituent of the Cannabis sativa plant,
has anti-seizure properties and does not produce euphoric or intrusive side effects. A plant …

Parkinson's disease (PD) research has largely focused on the disease as a single entity
centred on the development of neuronal pathology within the central nervous system …

Developmental and epileptic encephalopathies are devastating disorders characterized by
epilepsy, intellectual disability, and other neuropsychiatric symptoms, for which available …

A call to arms against ultra-rare diseases | Nature Biotechnology Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

In this article we briefly examine the unique features of Single-Case Designs (SCDs)(studies
in a single participant), their history and current trends, and real-world clinical applications …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder with limited available
therapies. There is progress in developing treatments for neuropsychiatric indications in AD …

The implementation of whole exome sequencing (WES) has had a major impact on the
diagnostic yield of genetic testing in individuals with epilepsy. The identification of a genetic …

Patients with ultrarare diseases present unique challenges to the health care systems of
developed economies that demand novel approaches, beginning with achieving a …

N-of-1 strategies can provide high-quality evidence of treatment efficacy at the individual
level and optimize evidence-based selection of off-label treatments for patients with rare …

Background Antidepressant discontinuation is associated with a broad range of adverse
effects. Debilitating discontinuation symptoms can impede the discontinuation process and …