Lipid–protein interactions in plasma membrane organization and function

T Sych, KR Levental, E Sezgin - Annual review of biophysics, 2022 - annualreviews.org
Lipid–protein interactions in cells are involved in various biological processes, including
metabolism, trafficking, signaling, host–pathogen interactions, and transmembrane …

The membrane surface as a platform that organizes cellular and biochemical processes

TA Leonard, M Loose, S Martens - Developmental cell, 2023 - cell.com
Membranes are essential for life. They act as semi-permeable boundaries that define cells
and organelles. In addition, their surfaces actively participate in biochemical reaction …

A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope

S Lee, JW Carrasquillo Rodrı́guez, H Merta… - Journal of Cell …, 2023 - rupress.org
Lipid composition determines organelle identity; however, whether the lipid composition of
the inner nuclear membrane (INM) domain of the ER contributes to its identity is not known …

Photoswitchable lipids

J Morstein, AC Impastato, D Trauner - ChemBioChem, 2021 - Wiley Online Library
Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid
function. They can modulate many aspects of membrane biophysics, including permeability …

Photoswitchable diacylglycerols enable optical control of protein kinase C

JA Frank, DA Yushchenko, DJ Hodson… - Nature chemical …, 2016 - nature.com
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream
signaling events including the translocation of C1-domain-containing proteins toward the …

Polyphenol compounds and PKC signaling

J Das, R Ramani, MO Suraju - … et Biophysica Acta (BBA)-General Subjects, 2016 - Elsevier
Background Naturally occurring polyphenols found in food sources provide huge health
benefits. Several polyphenolic compounds are implicated in the prevention of disease …

Photopharmacological control of cell signaling with photoswitchable lipids

TK Mukhopadhyay, J Morstein, D Trauner - Current Opinion in …, 2022 - Elsevier
Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been
functionalized with an azobenzene photoswitch to control underlying signaling dynamics …

Membrane shape as determinant of protein properties

JC Bozelli Jr, SS Aulakh, RM Epand - Biophysical Chemistry, 2021 - Elsevier
Membrane lipids play a role in the modulation of a variety of biological processes. This is
often achieved through fine-tuned changes in membrane physical and chemical properties …

The TORC2-Dependent Signaling Network in the Yeast Saccharomyces cerevisiae

FM Roelants, KL Leskoske, MN Martinez Marshall… - Biomolecules, 2017 - mdpi.com
To grow, eukaryotic cells must expand by inserting glycerolipids, sphingolipids, sterols, and
proteins into their plasma membrane, and maintain the proper levels and bilayer distribution …

Structure and function of STAC proteins: Calcium channel modulators and critical components of muscle excitation–contraction coupling

B Rufenach, F Van Petegem - Journal of Biological Chemistry, 2021 - ASBMB
In skeletal muscle tissue, an intriguing mechanical coupling exists between two ion
channels from different membranes: the L-type voltage-gated calcium channel (Ca V 1.1) …