TSLP: an epithelial cell cytokine that regulates T cell differentiation by conditioning dendritic cell maturation

YJ Liu, V Soumelis, N Watanabe, T Ito… - Annu. Rev …, 2007 - annualreviews.org
Dendritic cells (DCs) are professional antigen-presenting cells that have the ability to sense
infection and tissue stress, sample and present antigen to T lymphocytes, and induce …

The biology of thymic stromal lymphopoietin (TSLP)

SF Ziegler, F Roan, BD Bell, TA Stoklasek… - Advances in …, 2013 - Elsevier
Originally shown to promote the growth and activation of B cells, thymic stromal
lymphopoietin (TSLP) is now known to have wide-ranging impacts on both hematopoietic …

TSLP and IL‐33 reciprocally promote each other's lung protein expression and ILC2 receptor expression to enhance innate type‐2 airway inflammation

S Toki, K Goleniewska, J Zhang, W Zhou… - Allergy, 2020 - Wiley Online Library
Background The epithelial cell‐derived danger signal mediators thymic stromal
lymphopoietin (TSLP) and IL‐33 are consistently associated with adaptive Th2 immune …

Thymic stromal lymphopoietin: master switch for allergic inflammation

YJ Liu - The Journal of experimental medicine, 2006 - rupress.org
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL) 7–like cytokine that triggers
dendritic cell–mediated T helper (Th) 2 inflammatory responses. TSLP is highly expressed …

A role for TSLP in the development of inflammation in an asthma model

A Al-Shami, R Spolski, J Kelly, A Keane-Myers… - The Journal of …, 2005 - rupress.org
Thymic stromal lymphopoietin (TSLP) is a cytokine that promotes CD4+ T cell homeostasis.
We now demonstrate that TSLP is required to mount a normal CD4+ T cell–mediated …

Aberrant STAT5 and PI3K/mTOR pathway signaling occurs in human CRLF2-rearranged B-precursor acute lymphoblastic leukemia

SK Tasian, MY Doral, MJ Borowitz… - Blood, The Journal …, 2012 - ashpublications.org
Adults and children with high-risk CRLF2-rearranged acute lymphoblastic leukemia (ALL)
respond poorly to current cytotoxic chemotherapy and suffer unacceptably high rates of …

Cell biology of IL-7, a key lymphotrophin

Q Jiang, WQ Li, FB Aiello, R Mazzucchelli… - Cytokine & growth factor …, 2005 - Elsevier
IL-7 is essential for the development and survival of T lymphocytes. This review is primarily
from the perspective of the cell biology of the responding T cell. Beginning with IL-7 receptor …

The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation

SA Corfe, CJ Paige - Seminars in immunology, 2012 - Elsevier
Interleukin-7 (IL-7) plays several important roles during B cell development including aiding
in; the specification and commitment of cells to the B lineage, the proliferation and survival of …

TSLP enhances the function of helper type 2 cells

M Kitajima, HC Lee, T Nakayama… - European journal of …, 2011 - Wiley Online Library
The cytokine thymic stromal lymphopoietin (TSLP) has been implicated in the development
and progression of allergic inflammation in both humans and mice. TSLP has been shown to …

Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7–induced signaling

Y Rochman, M Kashyap… - Proceedings of the …, 2010 - National Acad Sciences
Thymic stromal lymphopoietin (TSLP) is a type I cytokine that plays essential roles in
allergic/inflammatory skin and airway disorders, in helminth infections, and in regulating …