Is the kidney a target of SARS-CoV-2?

MA Martinez-Rojas, O Vega-Vega… - American Journal of …, 2020 - journals.physiology.org
The new disease produced by severe acute respiratory syndrome-coronavirus 2 (SARS-
CoV-2) represents a major pandemic event nowadays. Since its origin in China in …

Angiotensin‐converting enzyme 2 (ACE2) is a key modulator of the renin angiotensin system in health and disease

C Tikellis, MC Thomas - International journal of peptides, 2012 - Wiley Online Library
Angiotensin‐converting enzyme 2 (ACE2) shares some homology with angiotensin‐
converting enzyme (ACE) but is not inhibited by ACE inhibitors. The main role of ACE2 is the …

[HTML][HTML] A multi-center retrospective cohort study defines the spectrum of kidney pathology in Coronavirus 2019 Disease (COVID-19)

RM May, C Cassol, A Hannoudi, CP Larsen… - Kidney international, 2021 - Elsevier
Kidney failure is common in patients with Coronavirus Disease-19 (COVID-19), resulting in
increased morbidity and mortality. In an international collaboration, 284 kidney biopsies …

Ang II (angiotensin II) conversion to angiotensin-(1-7) in the circulation is POP (prolyloligopeptidase)-dependent and ACE2 (angiotensin-converting enzyme 2) …

P Serfozo, J Wysocki, G Gulua, A Schulze, M Ye… - …, 2020 - Am Heart Assoc
The Ang II (Angiotensin II)-Angiotensin-(1-7) axis of the Renin Angiotensin System
encompasses 3 enzymes that form Angiotensin-(1-7)[Ang-(1-7)] directly from Ang II: ACE2 …

Urinary angiotensin-converting enzyme 2 in hypertensive patients may be increased by olmesartan, an angiotensin II receptor blocker

M Furuhashi, N Moniwa, T Mita, T Fuseya… - American journal of …, 2015 - academic.oup.com
BACKGROUND Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney
and converts angiotensin (Ang) II to Ang-(1–7), a renoprotective peptide. Urinary ACE2 has …

Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: implications for albuminuria in diabetes

M Ye, J Wysocki, J William, MJ Soler… - Journal of the …, 2006 - journals.lww.com
Abstract Angiotensin-converting enzyme 2 (ACE2) expression has been shown to be altered
in renal tubules from diabetic mice. This study examined the localization of ACE and ACE2 …

ACE inhibition, ACE2 and angiotensin-(1⿿ 7) axis in kidney and cardiac inflammation and fibrosis

ACS e Silva, MM Teixeira - Pharmacological research, 2016 - Elsevier
Abstract The Renin Angiotensin System (RAS) is a pivotal physiological regulator of heart
and kidney homeostasis, but also plays an important role in the pathophysiology of heart …

The emerging role of ACE2 in physiology and disease

I Hamming, ME Cooper, BL Haagmans… - The Journal of …, 2007 - Wiley Online Library
The renin–angiotensin–aldosterone system (RAAS) is a key regulator of systemic blood
pressure and renal function and a key player in renal and cardiovascular disease. However …

Патологическая анатомия инфекции, вызванной SARS-CoV-2

ЕА Коган, ЮС Березовский, ДД Проценко… - Судебная …, 2020 - cyberleninka.ru
Материалом для исследования послужили данные 80 аутопсий пациентов, страдавших
инфекцией COVID-19. При помощи макрои микроскопического исследований …

Angiotensin‐converting enzyme 2 in the brain: properties and future directions

H Xia, E Lazartigues - Journal of neurochemistry, 2008 - Wiley Online Library
Abstract Angiotensin (Ang)‐converting enzyme (ACE) 2 cleaves Ang‐II into the vasodilator
peptide Ang‐(1–7), thus acting as a pivotal element in balancing the local effects of these …