N-linked glycosylation is a post-translational modification crucial for membrane protein
folding, stability and other cellular functions. Alteration of membrane protein N-glycans is …

A growing amount of evidence suggests that ubiquitination and deubiquitination of
programmed death 1 (PD-1)/programmed death-ligand 1 (PD-L1) play crucial roles in the …

Breast cancer is the most frequent malignancy in women worldwide, and triple-negative
breast cancer (TNBC) patients have the worst prognosis and highest risk of recurrence. The …

Prostate cancers are largely unresponsive to immune checkpoint inhibitors (ICIs), and there
is strong evidence that programmed death-ligand 1 (PD-L1) expression itself must be …

Cancer is a disease caused by abnormal cell growth that spreads through other parts of the
body and threatens life by destroying healthy tissues. Therefore, numerous techniques have …

The B7/CD28 families of immune checkpoints play vital roles in negatively or positively
regulating immune cells in homeostasis and various diseases. Recent basic and clinical …

The anti-PD-L1 immunotherapy has shown promise in treating cancer. However, certain
patients with metastatic cancer have low response and high relapse rates. A main reason is …

Simple Summary Ovarian cancer (OC) represents the fifth leading cause of cancer-related
deaths among women. In the advanced disease setting, OC recurrence after chemotherapy …

Cancer immunotherapy using anti‐programmed death‐ligand 1 (PD‐L1) antibodies has
been used in various clinical applications and achieved certain results. However, such …

Dysregulated Epiregulin (EREG) can activate epidermal growth factor receptor (EGFR) and
promote tumor progression in head and neck squamous cell carcinoma (HNSCC). However …