Assessment of mechanisms in localized and widespread musculoskeletal pain

T Graven-Nielsen, L Arendt-Nielsen - Nature Reviews Rheumatology, 2010 - nature.com
The aim of this Review is to give a short presentation of the manifestations, assessment
methods, and mechanisms underlying localized and widespread musculoskeletal pain …

Human surrogate models of central sensitization: A critical review and practical guide

C Quesada, A Kostenko, I Ho, C Leone… - … Journal of pain, 2021 - Wiley Online Library
Background As in other fields of medicine, development of new medications for
management of neuropathic pain has been difficult since preclinical rodent models do not …

Changes in structure and function of the back muscles in low back pain: different time points, observations, and mechanisms

PW Hodges, L Danneels - Journal of orthopaedic & sports physical …, 2019 - jospt.org
Spinal health depends on optimal back muscle performance, and this is determined by
muscle structure and function. There has been substantial research evaluating the …

Psychophysical and functional imaging evidence supporting the presence of central sensitization in a cohort of osteoarthritis patients

SE Gwilym, JR Keltner, CE Warnaby… - Arthritis Care & …, 2009 - Wiley Online Library
Objective The groin pain experienced by patients with hip osteoarthritis (OA) is often
accompanied by areas of referred pain and changes in skin sensitivity. We aimed to identify …

Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects

KA Pollak, JD Swenson, TA Vanhaitsma… - Experimental …, 2014 - Wiley Online Library
New Findings What is the central question of this study? Can physiological concentrations of
metabolite combinations evoke sensations of fatigue and pain when injected into skeletal …

Human experimental pain models for assessing the therapeutic efficacy of analgesic drugs

AE Olesen, T Andresen, C Staahl, AM Drewes… - Pharmacological …, 2012 - Elsevier
Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Basic aspects of musculoskeletal pain: from acute to chronic pain

L Arendt-Nielsen… - Journal of Manual & …, 2011 - Taylor & Francis
The transition from acute to chronic musculoskeletal pain is not well understood. To
understand this transition, it is important to know how peripheral and central sensitization …

Pain treatment for patients with osteoarthritis and central sensitization

E Lluch Girbés, J Nijs, R Torres-Cueco… - Physical …, 2013 - academic.oup.com
Osteoarthritis is one of the most frequent, disabling, and costly pathologies of modern
society. Among the main aims of osteoarthritis management are pain control and functional …

On functional motor adaptations: from the quantification of motor strategies to the prevention of musculoskeletal disorders in the neck–shoulder region

P Madeleine - Acta Physiologica, 2010 - Wiley Online Library
Background: Occupations characterized by a static low load and by repetitive actions show a
high prevalence of work‐related musculoskeletal disorders (WMSD) in the neck–shoulder …

Effect of scapular function training on chronic pain in the neck/shoulder region: a randomized controlled trial

CH Andersen, LL Andersen, MK Zebis… - Journal of occupational …, 2014 - Springer
Purpose Neck and shoulder complaints are common among employees in occupations
characterized by intensive computer use. Treatment has varied from passive rest to active …