Regulation and function of the human HSP90AA1 gene
AD Zuehlke, K Beebe, L Neckers, T Prince - Gene, 2015 - Elsevier
Heat shock protein 90α (Hsp90α), encoded by the HSP90AA1 gene, is the stress inducible
isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different …
isoform of the molecular chaperone Hsp90. Hsp90α is regulated differently and has different …
[HTML][HTML] Broad action of Hsp90 as a host chaperone required for viral replication
Viruses are intracellular pathogens responsible for a vast number of human diseases. Due
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …
to their small genome size, viruses rely primarily on the biosynthetic apparatus of the host for …
Medicinal chemistry strategies toward host targeting antiviral agents
X Ji, Z Li - Medicinal Research Reviews, 2020 - Wiley Online Library
Direct‐acting antiviral agents (DAAs) represent a class of drugs targeting viral proteins and
have been demonstrated to be very successful in combating viral infections in clinic …
have been demonstrated to be very successful in combating viral infections in clinic …
Animal models for Ebola and Marburg virus infections
E Nakayama, M Saijo - Frontiers in microbiology, 2013 - frontiersin.org
Ebola and Marburg hemorrhagic fevers (EHF and MHF) are caused by the Filoviridae family,
Ebolavirus and Marburgvirus (ebolavirus and marburgvirus), respectively. These severe …
Ebolavirus and Marburgvirus (ebolavirus and marburgvirus), respectively. These severe …
Zika virus dependence on host Hsp70 provides a protective strategy against infection and disease
The spread of mosquito-borne Zika virus (ZIKV), which causes neurological disorders and
microcephaly, highlights the need for countermeasures against sudden viral epidemics …
microcephaly, highlights the need for countermeasures against sudden viral epidemics …
Multiple cationic amphiphiles induce a Niemann-Pick C phenotype and inhibit Ebola virus entry and infection
CJ Shoemaker, KL Schornberg, SE Delos, C Scully… - PloS one, 2013 - journals.plos.org
Ebola virus (EBOV) is an enveloped RNA virus that causes hemorrhagic fever in humans
and non-human primates. Infection requires internalization from the cell surface and …
and non-human primates. Infection requires internalization from the cell surface and …
Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses
Specific host pathways that may be targeted therapeutically to inhibit the replication of Ebola
virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 …
virus (EBOV) and other emerging viruses remain incompletely defined. A screen of 200,000 …
Advances in designing and developing vaccines, drugs, and therapies to counter Ebola virus
Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …
HSP90: a promising broad-spectrum antiviral drug target
Y Wang, F Jin, R Wang, F Li, Y Wu, K Kitazato… - Archives of …, 2017 - Springer
The emergence of antiviral drug-resistant mutants is the most important issue in current
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …
antiviral therapy. As obligate parasites, viruses require host factors for efficient replication …
The interaction of viruses with the cellular senescence response
R Seoane, S Vidal, YH Bouzaher, A El Motiam, C Rivas - Biology, 2020 - mdpi.com
Simple Summary Cellular senescence is considered a stress response that protects cells
against malignant transformation, facilitates tissue repair and development, and prevents …
against malignant transformation, facilitates tissue repair and development, and prevents …