Extracellular vesicles (EVs) are gaining increasing attention for diagnostic and therapeutic
applications in various diseases. These natural nanoparticles benefit from favorable safety …

Extracellular vesicles (EVs) are biocompatible, nano‐sized secreted vesicles containing
many types of biomolecules, including proteins, RNAs, DNAs, lipids, and metabolites. Their …

Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

The innate immune system plays a crucial role in the host defense against viral and
microbial infection. Exosomes constitute a subset of extracellular vesicles (EVs) that can be …

Extracellular vesicles (EVs) are secreted by almost all cells. They contain proteins, lipids,
and nucleic acids which are delivered from the parent cells to the recipient cells. Thereby …

Hepatocellular carcinoma (HCC, also called primary liver cancer) is one of the most fatal
cancers in the world. Due to the insidiousness of the onset of HCC and the lack of effective …

The narrow membrane necks formed during viral, exosomal and intra-endosomal budding
from membranes, as well as during cytokinesis and related processes, have interiors that …

Multivesicular bodies (MVBs) deliver cargo destined for degradation to the vacuole or
lysosome. The ESCRT (endosomal sorting complex required for transport) pathway is a key …

When internalized receptors and other cargo are destined for lysosomal degradation, they
are ubiquitinated and sorted by the endosomal sorting complex required for transport …