I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between
hepatic glucose production and glucose utilization by the major insulin-dependent tissues …

▪ Abstract The potent immunosuppressive drugs FK506 and rapamycin interfere with signal
transduction pathways required for T cell activation and growth. The distinct inhibitory effects …

Using transgenic mouse models, cell line-based functional studies, and clinical specimens,
we show that cyclin D1/CDK4 mediate resistance to targeted therapy for HER2-positive …

THE structurally related natural products rapamycin and FK506 bind to the same
intracellular receptor, FKBP12, yet the resulting complexes interfere with distinct signalling …

High-resistance exercise training results in an increase in muscle wet mass and protein
content. To begin to address the acute changes following a single bout of high-resistance …

The mammalian target of rapamycin (mTOR) integrates nutrient and mitogen signals to
regulate cell growth (increased cell mass and cell size) and cell division. The …

Saccharomyces cerevisiae cells treated with the immunosuppressant rapamycin or depleted
for the targets of rapamycin TOR1 and TOR2 arrest growth in the early G1 phase of the cell …

In rat hepatocytes, autophagy is known to be inhibited by amino acids. Insulin and cell
swelling promote inhibition by amino acids. Each of the conditions leading to inhibition of …

The proteins eIF-4E BP1 and p70 S6 kinase each undergo an insulin/mitogen-stimulated
phosphorylation in situ that is partially inhibited by rapamycin. Previous work has …

During the evolution of metazoans and the rise of systemic hormonal regulation, the insulin-
controlled class 1 phosphatidylinositol 3OH-kinase (PI3K) pathway was merged with the …