Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Cardiac fibrosis is central to the pathology of heart failure, particularly heart failure with
preserved ejection fraction (HF p EF). Irrespective of the underlying profibrotic condition (eg …

Due to its high degree of contagiousness and like almost no other virus, SARS-CoV-2 has
put the health of the world population on alert. COVID-19 can provoke an acute inflammatory …

Aldosterone, a vital hormone of the human body, has various pathophysiological roles. The
excess of aldosterone, also known as primary aldosteronism, is the most common …

Diabetic cardiomyopathy (DCM), a common consequence of longstanding diabetes mellitus,
is initiated by death of cardiomyocyte. Hyperglycemia-induced reactive oxygen species …

As a family of hormones with pleiotropic effects, natriuretic peptide (NP) system includes
atrial NP (ANP), B-type NP (BNP), C-type NP (CNP), dendroaspis NP and urodilatin, with NP …

Chronic inflammation and persistent oxidative stress contribute to the development and
progression of vascular proliferative diseases. We hypothesized that the proinflammatory …

Primary aldosteronism (PA) is a common cause of secondary hypertension and is
associated with worse cardiovascular outcomes. The elevated aldosterone in PA leads to …

Diabetic cardiomyopathy (DCM) is a vital cause of fatalities in diabetic patients. The
programmed death of cardiomyocytes and inflammation critically contribute to cardiac …