Neonicotinoids have been used to protect crops and animals from insect pests since the
1990s, but there are concerns regarding their adverse effects on nontarget organisms …

Nicotinic receptors—a family of ligand-gated ion channels that mediate the effects of the
neurotransmitter acetylcholine—are among the most well understood allosteric membrane …

Nicotinic acetylcholine, serotonin type 3, γ-amminobutyric acid type A, and glycine receptors
are major players of human neuronal communication. They belong to the family of …

The Monod-Wyman-Changeux (MWC) model was conceived in 1965 to account for the
signal transduction and cooperative properties of bacterial regulatory enzymes and …

Exactly 50 years ago, biochemists raised the question of the mechanism of the
conformational change that mediates “allosteric” interactions between regulatory sites and …

Cholinergic system is an important system and a branch of the autonomic nervous system
which plays an important role in memory, digestion, control of heart beat, blood pressure …

To identify high-affinity interactions between long-chain α-neurotoxins and nicotinic
receptors, we determined the crystal structure of the complex between α-btx (α …

Pharmacophore models for nicotinic agonists have been proposed for four decades. Central
to these models is the presence of a cationic nitrogen and a hydrogen bond acceptor. It is …

Marine cone snails are a large family of gastropods that have evolved highly potent venoms
for predation and defense. The cone snail venom has exceptional molecular diversity in …

Determining the structure of the ligand-binding domain of the nicotinic acetylcholine receptor
(nAChR) has been a long standing goal in the design of selective drugs useful in implicated …