Same substrate, many reactions: oxygen activation in flavoenzymes
Over time, organisms have evolved strategies to cope with the abundance of dioxygen on
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Earth. Oxygen-utilizing enzymes tightly control the reactions involving O2 mostly by …
Crosstalk of physiological pH and chemical pKa under the umbrella of physiologically based pharmacokinetic modeling of drug absorption, distribution, metabolism …
L Gaohua, X Miao, L Dou - Expert opinion on drug metabolism & …, 2021 - Taylor & Francis
Introduction: Physiological pH and chemical pKa are two sides of the same coin in defining
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …
the ionization of a drug in the human body. The Henderson-Hasselbalch equation and pH …
[图书][B] A textbook of modern toxicology
E Hodgson - 2011 - books.google.com
A Textbook of Modern Toxicology is a unique resource that provides both students and
practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses …
practitioners with a wide-ranging, accessible overview of the discipline. Suitable for courses …
Gut Microbiota-Dependent Trimethylamine-N-oxide and Serum Biomarkers in Patients with T2DM and Advanced CKD
MAI Al-Obaide, R Singh, P Datta… - Journal of clinical …, 2017 - mdpi.com
Trimethylamine-N-oxide (TMAO) is a product of dietary, gut microbiome, and tissues
metabolism. Elevated blood TMAO levels are associated with heart attack, stroke and …
metabolism. Elevated blood TMAO levels are associated with heart attack, stroke and …
Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism
SK Krueger, DE Williams - Pharmacology & therapeutics, 2005 - Elsevier
Flavin-containing monooxygenase (FMO) oxygenates drugs and xenobiotics containing a
“soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a …
“soft-nucleophile”, usually nitrogen or sulfur. FMO, like cytochrome P450 (CYP), is a …
Salicylic Acid–Independent ENHANCED DISEASE SUSCEPTIBILITY1 Signaling in Arabidopsis Immunity and Cell Death Is Regulated by the Monooxygenase FMO1 and the …
M Bartsch, E Gobbato, P Bednarek, S Debey… - The Plant …, 2006 - academic.oup.com
Abstract Arabidopsis thaliana ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1) controls
defense activation and programmed cell death conditioned by intracellular Toll-related …
defense activation and programmed cell death conditioned by intracellular Toll-related …
Metabolism of xenobiotics of human environments
E Croom - Progress in molecular biology and translational …, 2012 - Elsevier
Xenobiotics have been defined as chemicals to which an organism is exposed that are
extrinsic to the normal metabolism of that organism. Without metabolism, many xenobiotics …
extrinsic to the normal metabolism of that organism. Without metabolism, many xenobiotics …
Isoform specificity of trimethylamine N-oxygenation by human flavin-containing monooxygenase (FMO) and P450 enzymes: selective catalysis by FMO3
DH Lang, CK Yeung, RM Peter, C Ibarra… - Biochemical …, 1998 - Elsevier
In the present study, we expressed human flavin-containing monooxygenase 1 (FMO1),
FMO3, FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of …
FMO3, FMO4t (truncated), and FMO5 in the baculovirus expression vector system at levels of …
Human flavin-containing monooxygenases
JR Cashman, J Zhang - Annu. Rev. Pharmacol. Toxicol., 2006 - annualreviews.org
▪ Abstract This review summarizes recent information concerning the pharmacological and
toxicological significance of the human flavin-containing monooxygenase (FMO, EC 1.14 …
toxicological significance of the human flavin-containing monooxygenase (FMO, EC 1.14 …
Missense mutation in flavin-containing mono-oxygenase 3 gene, FMO3, underlies fish-odour syndrome
CT Dolphin, A Janmohamed, RL Smith, EA Shephard… - Nature …, 1997 - nature.com
Individuals with primary trimethylaminuria exhibit a body odour reminiscent of rotting fish,
due to excessive excretion of trimethylamine (TMA; refs 1–3). The disorder, colloquially …
due to excessive excretion of trimethylamine (TMA; refs 1–3). The disorder, colloquially …